The recently discovered epithelial sodium channel (ENaC)/degenerin (DEG) gene family
encodes sodium channels involved in various cell functions in metazoans. Subfamilies found in …

The Concise Guide to PHARMACOLOGY 2017/18 is the third in this series of biennial
publications. This version provides concise overviews of the key properties of nearly 1800 human …

… Under a normal salt diet, mice heterozygous (L/+) and homozygous (L/L) for the Liddle
mutation (L) develop normally during the first 3 months of life. In these mice, blood pressure is not …

THE amiloride-sensitive epithelial sodium channel constitutes the rate-limiting step for sodium
reabsorption in epithelial cells that line the distal part of the renal tubule, the distal colon, …

The epithelial Na+ channel (ENaC), composed of three subunits (αβγ), plays a critical role
in salt and fluid homeostasis. Abnormalities in channel opening and numbers have been …

Neuroblastoma is a childhood tumour of the peripheral sympathetic nervous system. The
pathogenesis has for a long time been quite enigmatic, as only very few gene defects were …

The majority of patients with neuroblastoma have tumors that initially respond to chemotherapy,
but a large proportion will experience therapy-resistant relapses. The molecular basis of …

… ), normal 3.5-5.0; PAC, plasma aldosterone concentration (g/l), normal 1–95. fr, frameshift.
Kindreds … Schild, L. et al. A mutation in the epithelial sodium channel causing Liddle's disease …

… Products were labelled by inclusion of l pCi of o-*P dCTP in the reaction mixture. After an
initial denaturation step at 94 C for 5 min, PCR was conducted for 30 cycles with denaturation …

… They were diluted in standard PBS (Sigma, NaCl 120 mmol l −1 , KCl 2.7 mmol l −1 , phosphate
buffer 10 mmol l −1 , pH 7.4) the conductance of which was measured at about 1.6 S m −…