User profiles for Laetitia Mony
Laetitia MonyPermanent researcher (CR2) at INSERM Verified email at mony.fr Cited by 1610 |
Allosteric modulators of NR2B‐containing NMDA receptors: molecular mechanisms and therapeutic potential
L Mony, JNC Kew, MJ Gunthorpe… - British journal of …, 2009 - Wiley Online Library
N‐methyl‐D‐aspartate receptors (NMDARs) are ion channels gated by glutamate, the major
excitatory neurotransmitter in the mammalian central nervous system (CNS). They are …
excitatory neurotransmitter in the mammalian central nervous system (CNS). They are …
Positive allosteric modulation of NMDA receptors: mechanisms, physiological impact and therapeutic potential
C Geoffroy, P Paoletti, L Mony - The Journal of Physiology, 2022 - Wiley Online Library
NMDA receptors (NMDARs) are glutamate‐gated ion channels that play key roles in synaptic
transmission and plasticity. Both hyper‐ and hypo‐activation of NMDARs are deleterious to …
transmission and plasticity. Both hyper‐ and hypo‐activation of NMDARs are deleterious to …
Mechanism of differential control of NMDA receptor activity by NR2 subunits
N-methyl-d-aspartate (NMDA) receptors (NMDARs) are a major class of excitatory neurotransmitter
receptors in the central nervous system. They form glutamate-gated ion channels that …
receptors in the central nervous system. They form glutamate-gated ion channels that …
Glycine agonism in ionotropic glutamate receptors
D Stroebel, L Mony, P Paoletti - Neuropharmacology, 2021 - Elsevier
Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that mediate the
majority of excitatory neurotransmission in the vertebrate CNS. Classified as AMPA, kainate, …
majority of excitatory neurotransmission in the vertebrate CNS. Classified as AMPA, kainate, …
Molecular basis of positive allosteric modulation of GluN2B NMDA receptors by polyamines
NMDA receptors (NMDARs) form glutamate‐gated ion channels that have central roles in
neuronal communication and plasticity throughout the brain. Dysfunctions of NMDARs are …
neuronal communication and plasticity throughout the brain. Dysfunctions of NMDARs are …
A novel binding mode reveals two distinct classes of NMDA receptor GluN2B-selective antagonists
…, PK Chanda, M Green, S Sciabola, L Mony… - Molecular …, 2016 - ASPET
N-methyl-d-aspartate receptors (NMDARs) are glutamate-gated ion channels that play key
roles in brain physiology and pathology. Because numerous pathologic conditions involve …
roles in brain physiology and pathology. Because numerous pathologic conditions involve …
GluD1 binds GABA and controls inhibitory plasticity
…, D Stroebel, C Charrier, AR Aricescu, L Mony… - Science, 2023 - science.org
Fast synaptic neurotransmission in the vertebrate central nervous system relies primarily on
ionotropic glutamate receptors (iGluRs), which drive neuronal excitation, and type A γ-…
ionotropic glutamate receptors (iGluRs), which drive neuronal excitation, and type A γ-…
Spectro− Temporal Characterization of the Photoactivation Mechanism of Two New Oxidized Cryptochrome/Photolyase Photoreceptors
The photoactivation dynamics of two new flavoproteins (OtCPF1 and OtCPF2) of the cryptochrome
photolyase family (CPF), belonging to the green alga Ostreococcus tauri , was studied …
photolyase family (CPF), belonging to the green alga Ostreococcus tauri , was studied …
A specialized molecular motion opens the Hv1 voltage-gated proton channel
L Mony, TK Berger, EY Isacoff - Nature structural & molecular biology, 2015 - nature.com
The Hv1 proton channel is unique among voltage-gated channels for containing the pore
and gate within its voltage-sensing domain. Pore opening has been proposed to include …
and gate within its voltage-sensing domain. Pore opening has been proposed to include …
Mechanisms of NMDA receptor regulation
L Mony, P Paoletti - Current Opinion in Neurobiology, 2023 - Elsevier
N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels widely expressed
in the central nervous system that play key role in brain development and plasticity. On …
in the central nervous system that play key role in brain development and plasticity. On …