User profiles for Laetitia Mony

Laetitia Mony

Permanent researcher (CR2) at INSERM
Verified email at mony.fr
Cited by 1610

Allosteric modulators of NR2B‐containing NMDA receptors: molecular mechanisms and therapeutic potential

L Mony, JNC Kew, MJ Gunthorpe… - British journal of …, 2009 - Wiley Online Library
N‐methyl‐D‐aspartate receptors (NMDARs) are ion channels gated by glutamate, the major
excitatory neurotransmitter in the mammalian central nervous system (CNS). They are …

Positive allosteric modulation of NMDA receptors: mechanisms, physiological impact and therapeutic potential

C Geoffroy, P Paoletti, L Mony - The Journal of Physiology, 2022 - Wiley Online Library
NMDA receptors (NMDARs) are glutamate‐gated ion channels that play key roles in synaptic
transmission and plasticity. Both hyper‐ and hypo‐activation of NMDARs are deleterious to …

Mechanism of differential control of NMDA receptor activity by NR2 subunits

M Gielen, BS Retchless, L Mony, JW Johnson… - Nature, 2009 - nature.com
N-methyl-d-aspartate (NMDA) receptors (NMDARs) are a major class of excitatory neurotransmitter
receptors in the central nervous system. They form glutamate-gated ion channels that …

Glycine agonism in ionotropic glutamate receptors

D Stroebel, L Mony, P Paoletti - Neuropharmacology, 2021 - Elsevier
Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that mediate the
majority of excitatory neurotransmission in the vertebrate CNS. Classified as AMPA, kainate, …

Molecular basis of positive allosteric modulation of GluN2B NMDA receptors by polyamines

L Mony, S Zhu, S Carvalho, P Paoletti - The EMBO journal, 2011 - embopress.org
NMDA receptors (NMDARs) form glutamate‐gated ion channels that have central roles in
neuronal communication and plasticity throughout the brain. Dysfunctions of NMDARs are …

A novel binding mode reveals two distinct classes of NMDA receptor GluN2B-selective antagonists

…, PK Chanda, M Green, S Sciabola, L Mony… - Molecular …, 2016 - ASPET
N-methyl-d-aspartate receptors (NMDARs) are glutamate-gated ion channels that play key
roles in brain physiology and pathology. Because numerous pathologic conditions involve …

GluD1 binds GABA and controls inhibitory plasticity

…, D Stroebel, C Charrier, AR Aricescu, L Mony… - Science, 2023 - science.org
Fast synaptic neurotransmission in the vertebrate central nervous system relies primarily on
ionotropic glutamate receptors (iGluRs), which drive neuronal excitation, and type A γ-…

Spectro− Temporal Characterization of the Photoactivation Mechanism of Two New Oxidized Cryptochrome/Photolyase Photoreceptors

…, C Ley, MM Martin, P Plaza, L Mony… - Journal of the …, 2010 - ACS Publications
The photoactivation dynamics of two new flavoproteins (OtCPF1 and OtCPF2) of the cryptochrome
photolyase family (CPF), belonging to the green alga Ostreococcus tauri , was studied …

A specialized molecular motion opens the Hv1 voltage-gated proton channel

L Mony, TK Berger, EY Isacoff - Nature structural & molecular biology, 2015 - nature.com
The Hv1 proton channel is unique among voltage-gated channels for containing the pore
and gate within its voltage-sensing domain. Pore opening has been proposed to include …

Mechanisms of NMDA receptor regulation

L Mony, P Paoletti - Current Opinion in Neurobiology, 2023 - Elsevier
N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels widely expressed
in the central nervous system that play key role in brain development and plasticity. On …