Kupffer cells are a critical component of the mononuclear phagocytic system and are central
to both the hepatic and systemic response to pathogens. Kupffer cells are reemerging as …

Chronic exposure to ethanol results in heterologous desensitization of receptors coupled to
adenylyl cyclase via Gs, the stimulatory guanine nucleotide regulatory protein. Ethanol-…

Hepatocyte cell death via apoptosis and necrosis are major hallmarks of ethanol‐induced
liver injury. However, inhibition of apoptosis is not sufficient to prevent ethanol‐induced …

Reactive oxygen species (ROS) contribute to the development of chronic ethanol-induced
liver injury. Although ROS modulate the activity of many signal transduction pathways, the …

▪ Abstract Alcohol metabolism takes place primarily in the liver. Initial exposures to ethanol
have a major impact on the hepatic redox state and intermediary metabolism as a …

Background Excessive alcohol consumption leads to liver disease. Interorgan crosstalk
contributes to ethanol ( EtOH )‐induced liver injury. EtOH exposure causes gut dysbiosis …

Chronic ethanol ingestion mildly damages liver through oxidative stress and lipid oxidation,
which is ameliorated by dietary supplementation with the anti-inflammatory β-amino acid …

The anti-inflammatory effects of globular adiponectin (gAcrp) are mediated by IL-10/heme
oxygenase 1 (HO-1)-dependent pathways. Although full-length (flAcrp) adiponectin also …

Frank Burr Mallory's landmark observation in 1911 on the histopathology of alcoholic liver
disease (ALD) was the first identification of a link between inflammation and ALD. In this review…

Inflammatory processes are primary contributors to the development and progression of
alcoholic steatohepatitis (ASH), with severe alcoholic hepatitis characterised by non-resolving …