The in vitro biotransformation of bupropion to hydroxybupropion was studied in human liver
microsomes and microsomes containing heterologously expressed human cytochromes …

Bupropion is primarily metabolized in human liver by cytochrome P450 (CYP) 2B6, an isoform
that shows high interindividual variability in expression and catalysis. The aim of this study …

The purpose of this study was to generate, by real-time PCR, a quantitative expression level
profile of the 19 human UDP-glucuronosyltransferases (UGTs) of subfamilies 1A, 2A and 2B…

The objective of this study was to use recombinant enzymes and human liver microsomes (HLMs)
to comprehensively evaluate the functional impact of the three most common …

Background Oxidation of propofol to 4-hydroxypropofol represents a significant pathway in
the metabolism of this anesthetic agent in humans. The aim of this study was to identify the …

Nicotine biotransformation affects the smoking habits of addicted individuals and therefore
their health risk. Using an improved analytical method, we have discovered that the human …

Insomnia, an inability to initiate or maintain sleep, affects approximately one-third of the
American population. Conventional benzodiazepines, such as triazolam and midazolam, were …

Aims The influence of ageing on the pharmacokinetics of zolpidem, an extensively prescribed
hypnotic medication, was evaluated in healthy human volunteers. Methods A series of 16 …

Since antiretroviral drugs are known to inhibit many cytochrome P450 isoforms, the inhibition
of CYP2B6 by non-nucleoside reverse transcriptase inhibitors and viral protease inhibitors …

… We also observed high concordance between UGT2B15 and HLM enzyme K m values
for S-oxazepam glucuronidation. On the other hand, R-oxazepam-glucuronide was formed …