As both a sensor of extracellular calcium (Ca 2+ o ) concentration and a key controller of Ca
2+ o homeostasis, one of the most interesting properties of the calcium-sensing receptor (…

Nephrotoxicity is a serious complication that limits the clinical use of gentamicin (GEN).
Parthenolide (PTL) is a sesquiterpene lactone derived from feverfew with various therapeutic …

Excessive architectural re-modeling of tissues in pulmonary fibrosis due to proliferation of
myofibroblasts and deposition of extracellular matrix adversely affects the elasticity of the …

Chemotherapy-induced peripheral neuropathy (CIPN) is one of chemotherapies’ most often
documented side effects. Patients with CIPN experience spontaneous burning, numbness, …

Acute respiratory distress syndrome (ARDS), a catastrophic illness of multifactorial etiology,
involves a rapid upsurge in inflammatory cytokines that leads to hypoxemic respiratory failure…

Endometrial hyperplasia (EH) is the most common risk factor for endometrial malignancy in
females. The pathogenesis of EH has been directly linked to uterine inflammation, which can …

Garcinia mangostana L. (Clusiaceae), a popular tropical fruit for its juiciness and sweetness,
is an opulent fountain of prenylated and oxygenated xanthones with a vast array of bio-…

The calcium-sensing receptor (CaS) is the principal controller of extracellular calcium (Ca 2+
o ) homeostasis and is inhibited in vitro and in vivo by protein kinase C (PKC)-mediated …

Introduction: Benign prostatic hyperplasia (BPH) is a common disease among elderly men.
Its pharmacological treatment is still unsatisfactory. 6-Paradol (6-PD) is an active metabolite …

Chlorpyrifos (CPF), is an organophosphate pesticide that is widely used for agricultural
purposes. However, it has well-documented hepatotoxicity. Lycopene (LCP) is a plant-derived …