The purpose of the present study was to determine whether a physiologic plasma concentration
of α-ketoglutarate (αKG) influences the kinetic interaction of ligands with organic anion …

The mechanism by which drugs inhibit organic anion transporter 1 (OAT1) was examined.
OAT1 was stably expressed in Chinese hamster ovary (CHO) cells, and para-aminohippurate (…

The ciliary epithelium is important for aqueous humor inflow and maintenance of intraocular
pressure. Treatment of ciliary epithelium with β‐adrenergic agonists leads to increased …

CONCLUSIONS: These results suggest that HCN-2 is predominant subtype of
hyperpolarization-activated cyclic nucleotide-gated cation channels, which can control neuronal …

In vitro studies that assess OAT1 activity study the protein in isolation, despite its reliance on
NaDC3. The purpose was to determine if NaDC3 can influence OAT1 activity in typical in …

Renal tubular drug secretion mediated by the organic anion transporter 1 (OAT1) is a
potential site of drug‐drug interactions. A number of marketed drugs inhibit OAT1, but the …

There are discrepancies in the literature regarding ligand selectivity of organic anion transporter
2 (OAT2). The purpose of this study was to re‐examine the interaction of ligands with …

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Despite the importance of extracellular α-ketoglutarate ( 54 αKG) for OAT1 transport in vivo,
in vitro studies to assess drug-drug interaction (DDI) potential at OAT1 are conducted in its …

There is a global emergence of multidrug-resistant (MDR) strains of Klebsiella pneumoniae
, a Gram-negative enteric bacterium that causes nosocomial and urinary tract infections. …