The mouse mdr1a (also called mdr3) P-GP is abundant in the blood-brain barrier, and its
absence in mdr1a (-/-) mice leads to highly increased levels of the drugs ivermectin, vinblastine…

The mdr1-type P-glycoproteins (P-gps) confer multidrug resistance to cancer cells by active
extrusion of a wide range of drugs from the cell. To study their physiological roles, we have …

Two prominent members of the ATP-binding cassette superfamily of transmembrane
proteins, multidrug resistance 1 (MDR1) P-glycoprotein and multidrug resistance protein 1 (MRP1), …

Inhibition of PARP is a promising therapeutic strategy for homologous recombination–deficient
tumors, such as BRCA1-associated cancers. We previously reported that BRCA1-…

The canalicular (apical) membrane of the hepatocyte contains an ATP-dependent transport
system for organic anions, known as the multispecific organic anion transporter (cMOAT). …

The human multidrug resistance proteins MRP4 and MRP5 are organic anion transporters
that have the unusual ability to transport cyclic nucleotides and some nucleoside …

The human multidrug resistance protein (MRP1) causes drug resistance by extruding drugs
from tumor cells. In addition to an MDR-like core, MRP1 contains an N-terminal membrane-…

The human multidrug resistance-associated protein MRP confers resistance to various
cytotoxic drugs by lowering the intracellular drug concentration. Recent evidence indicates that …

Despite accumulating evidence that multidrug resistance transporter proteins play a part in
drug resistance in some clinical cancers, it remains unclear whether the relatively low levels …

Heterozygous germline mutations in breast cancer 1 (BRCA1) strongly predispose women to
breast cancer. BRCA1 plays an important role in DNA double-strand break (DSB) repair via …