PI 3‐kinase regulation of dopamine uptake

L Carvelli, JA Morón, KM Kahlig… - Journal of …, 2002 - Wiley Online Library
The magnitude and duration of dopamine (DA) signaling is defined by the amount of
vesicular release, DA receptor sensitivity, and the efficiency of DA clearance, which is largely …

Amphetamine-induced loss of human dopamine transporter activity: an internalization-dependent and cocaine-sensitive mechanism

…, LMF Leeb-Lundberg, L Carvelli… - Proceedings of the …, 2000 - National Acad Sciences
The dopamine transporter (DAT) is a target of amphetamine (AMPH) and cocaine. These
psychostimulants attenuate DAT clearance efficiency, thereby increasing synaptic dopamine (…

Dopamine transporter/syntaxin 1A interactions regulate transporter channel activity and dopaminergic synaptic transmission

L Carvelli, RD Blakely… - Proceedings of the …, 2008 - National Acad Sciences
The Caenorhabditis elegans (C. elegans) dopamine (DA) transporter (DAT-1) regulates DA
signaling through efficient DA reuptake following synaptic release. In addition to its DA …

SLC6 transporters: structure, function, regulation, disease association and therapeutics

AB Pramod, J Foster, L Carvelli, LK Henry - Molecular aspects of medicine, 2013 - Elsevier
The SLC6 family of secondary active transporters are integral membrane solute carrier
proteins characterized by the Na + -dependent translocation of small amino acid or amino acid-…

Transgenic SOD1 G93A mice develop reduced GLT‐1 in spinal cord without alterations in cerebrospinal fluid glutamate levels

…, SK Suchak, N Calvaresi, L Carvelli… - Journal of …, 2001 - Wiley Online Library
Glutamate‐induced excitotoxicity is suggested to play a central role in the development of
amyotrophic lateral sclerosis (ALS), although it is still unclear whether it represents a primary …

Dopamine transporters depolarize neurons by a channel mechanism

L Carvelli, PW McDonald… - Proceedings of the …, 2004 - National Acad Sciences
Neurotransmitter transporters generate larger currents than expected if one assumes fixed
stoichiometry models. It remains controversial, however, whether these depolarizing currents …

Vigorous motor activity in Caenorhabditis elegans requires efficient clearance of dopamine mediated by synaptic localization of the dopamine transporter DAT-1

…, SL Hardie, TN Jessen, L Carvelli… - Journal of …, 2007 - Soc Neuroscience
The catecholamine dopamine (DA) functions as a powerful modulatory neurotransmitter in
both invertebrates and vertebrates. As in man, DA neurons in the nematode Caenorhabditis …

A genetic screen in Caenorhabditis elegans for dopamine neuron insensitivity to 6‐hydroxydopamine identifies dopamine transporter mutants impacting transporter …

…, T Jessen, PW McDonald, L Carvelli… - Journal of …, 2005 - Wiley Online Library
The presynaptic dopamine (DA) transporter (DAT) is a major determinant of synaptic DA
inactivation, an important target for psychostimulants including cocaine and amphetamine, and …

Molecular mechanisms of amphetamine actions in Caenorhabditis elegans

L Carvelli, DS Matthies, A Galli - Molecular pharmacology, 2010 - ASPET
Amphetamine (AMPH) poses a serious hazard to public health. Defining the molecular targets
of AMPH is essential to developing treatments for psychostimulant abuse. AMPH elicits its …

Glial expression of the Caenorhabditis elegans gene swip-10 supports glutamate dependent control of extrasynaptic dopamine signaling

…, WC Spencer, DM Miller, L Carvelli… - Journal of …, 2015 - Soc Neuroscience
Glial cells play a critical role in shaping neuronal development, structure, and function. In a
screen for Caenorhabditis elegans mutants that display dopamine (DA)-dependent, …