Many carboxylic acid-containing drugs undergo conjugation with D-glucuronic acid in
humans, leading to the formation of acyl glucuronides, which are excreted into urine. However, …

… The washed proteins were then treated with 1 ml ofNaOH 2 M at 60#{176}Cfor 4 hr. After
acidification … solutions were prepared in an isotonic SOrensen 0.067 M phosphate …

Equilibrium dialysis was used to study in vitro the enantioselective binding of R, S, and racemic
ketoprofen at physiological pH and temperature in human serum albumin (HSA) (1, 20, …

Endoscopic lesions of the gastric mucosa were evaluated in 12 healthy volunteers after
administration of single doses of ketoprofen (25 mg), ibuprofen (200 mg) and aspirin (500 mg) in …

… of the ultrafiltration technique resulted in the discrimination of two binding sites having affinity
constants of 7.8 x 105 M -1 and 7.7 × 104 M -] [16]. By ultrafiltration Iwakawa et al. [13] also …

The conduct of clinical trials falls within a strict regulatory framework. The objective of the
round table was to develop reasonable recommendations for the implementation of GCP …

The aim of the Round Table was to make recommendations with regard to the imminent
revision of the European Directive on clinical drug trials (2001/20/CE). While recognising the …

… M..… Berger, C., Miersch, M. Zum normalen Verkommen von Neisseria Mucosa. Z Med
Mikrobiol Immun, 1970, 155, 186-190. … Veron, M., Riou, JY A propos des observations …

In elderly patients, nonsteroidal anti-inflammatory drugs (NSAIDs) are often used
concomitantly with antihypertensive agents. It is therefore important to assess the potential for …

Objective—To assess the safety, tolerability and efficacy of low‐dose ketoprofen (75–150
mg daily for 5 to 15 days) in a general practice setting. Design—Open label, non‐controlled …