[PDF][PDF] G-protein-coupled receptor signaling in neuroendocrine systems. Thyrotropin-releasing hormone receptors—Similarities and differences

Y Sun, X Lu, MC Gershengorn - J. Mol. Endocrinol, 2003 - Citeseer
Thyrotropin-releasing hormone (TRH) initiates its effects by interacting with cell-surface
membrane receptors. Two G protein-coupled receptors for TRH, TRH receptor type 1 (TRH-R1) …

Molecular and cellular biology of thyrotropin-releasing hormone receptors

MC Gershengorn, R Osman - Physiological reviews, 1996 - journals.physiology.org
… Perlman and Gershengorn (95) confirmed the finding that TRH-stimulated … (123) and Perlman
and Gershengorn (95) attempted to gain insight into the specific protein kinase(s) that may …

Mechanism of thyrotropin releasing hormone stimulation of pituitary hormone secretion

MC Gershengorn - Annual Review of Physiology, 1986 - annualreviews.org
… Rebecchi, MJ, Monaco, ME, Ger shengorn, MC 1981. >Thyrotropin releasing hormone rapidly
enhances [… Sobel, A., Boutterin, MC 1985. Cytoplasmic protein phosphorylation re lated to …

Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation

…, E Geras-Raaka, A Varma, MC Gershengorn… - Nature, 1997 - nature.com
Kaposi's sarcoma-associated herpesvirus (KSHV, also known as human herpesvirus 8, or
HHV 8) is a virus that is consistently present in Kaposi's sarcoma 1,2 and in primary-effusion (…

Epithelial-to-mesenchymal transition generates proliferative human islet precursor cells

MC Gershengorn, AA Hardikar, C Wei, E Geras-Raaka… - Science, 2004 - science.org
Insulin-expressing beta cells, found in pancreatic islets, are capable of generating more beta
cells even in the adult. We show that fibroblast-like cells derived from adult human islets …

Human pancreatic precursor cells secrete FGF2 to stimulate clustering into hormone-expressing islet-like cell aggregates

…, BM Raaka, MC Gershengorn - Proceedings of the …, 2003 - National Acad Sciences
Development of the endocrine pancreas includes a series of early events wherein precursor
cells cluster, that is migrate to form cell aggregates, which subsequently differentiate into …

TSH/IGF-1 receptor cross talk in Graves' ophthalmopathy pathogenesis

…, S Neumann, MC Gershengorn - The Journal of …, 2016 - academic.oup.com
Context: The TSH receptor (TSHR) is considered the main target of stimulatory autoantibodies
in the pathogenesis of Graves' ophthalmopathy (GO); however, it has been suggested that …

Thyrotropin-induced hyperthyroidism caused by selective pituitary resistance to thyroid hormone. A new syndrome of

MC Gershengorn, BD Weintraub - The Journal of clinical …, 1975 - Am Soc Clin Investig
An 18-yr-old woman with clinical and laboratory features of hyperthyroidism had persistently
elevated serum levels of immunoreative thyrotropin (TSH). During 11 yr of follow-up there …

Bidirectional TSH and IGF-1 receptor cross talk mediates stimulation of hyaluronan secretion by Graves' disease immunoglobins

…, B Marcus-Samuels, MC Gershengorn - The Journal of …, 2015 - academic.oup.com
Context: There is no pathogenetically linked medical therapy for Graves' ophthalmopathy (GO).
Lack of animal models and conflicting in vitro studies have hindered the development of …

Discovery of novel agonists and antagonists of the free fatty acid receptor 1 (FFAR1) using virtual screening

…, BM Raaka, S Costanzi, MC Gershengorn - Journal of medicinal …, 2008 - ACS Publications
The G-protein-coupled receptor free fatty acid receptor 1 (FFAR1), previously named GPR40,
is a possible novel target for the treatment of type 2 diabetes. In an attempt to identify new …