The expression and inducibility of four CYP2C genes, including CYP2C8, -2C9, -2C18, and
-2C19, was investigated in primary cultures of human hepatocytes. By the use of RNase …

… mm Tris-HCl, pH 7.2, 100 mm KCl, 1 mm DTT in the presence of 4 μg of total proteins
from Sf9 cells transfected with a recombinant GR-expressing baculovirus and Nonidet P-40 (0.1%) …

The marked impairment of hepatic drug metabolism during inflammation and infections has
been known for many years and shown to result from down-regulation of cytochrome P450s (…

Omeprazole is a new drug used for its high efficiency as an inhibitor of gastric acid secretion.
This substituted benzimidazole molecule had been shown to decrease several liver …

… 96 h in the absence or presence of 50 μm of various imidazole derivatives. These included
… oxidase) with a K i < 1 μm. Clotrimazole and miconazole were also strong inhibitors of P450 …

Prednisone, prednisolone, and methylprednisolone are currently administered in association
with cyclosporin A in the postoperative treatment of transplant patients. The aim of this work …

Omeprazole is a benzimidazole derivative which induces both P450 1A1 and 1A2 in human
liver in vitro and in vivo. Northern blot analysis of polyA RNA prepared from primary cultures …

… in 500 Ml of 0.1 M potassium … in the presence of 5 ,M ethoxyresorufin … in 500 l of 0.1
M potassium phosphate buffer, pH 7.4, and were incubated …

PlantRNA database ( http://plantrna.ibmp.cnrs.fr/ ) compiles transfer RNA (tRNA) gene
sequences retrieved from fully annotated plant nuclear, plastidial and mitochondrial genomes. …

The expression of many genes involved in xenobiotic/drug metabolism and transport is
regulated by at least three nuclear receptors or xenosensors: aryl hydrocarbon receptor (AhR), …