User profiles for M Lazdunski

michel lazdunski

Professeur,Institute Molecular Pharmacology,CNRS,UCA,Nice-Sophia Antipolis
Verified email at ipmc.cnrs.fr
Cited by 84359

A proton-gated cation channel involved in acid-sensing

…, F Bassilana, C Heurteaux, M Lazdunski - Nature, 1997 - nature.com
… & Lazdunski, M. The nammalian degenerin MDEG, an amiloride-sensitive cation channel …
& Lazdunski, M. Functional degenerin-containing chimeras identify residues essential for …

International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels

GA Gutman, KG Chandy, S Grissmer, M Lazdunski… - Pharmacological …, 2005 - ASPET
Potassium-selective channels are the largest and most diverse group of ion channels,
represented by some 70 known loci in the mammalian genome. The first cloned potassium …

Molecular and functional properties of two-pore-domain potassium channels

F Lesage, M Lazdunski - American Journal of Physiology …, 2000 - journals.physiology.org
The two-pore-domain K + channels, or K 2P channels, constitute a novel class of K + channel
subunits. They have four transmembrane segments and are active as dimers. The tissue …

KvLQT1 and IsK (minK) proteins associate to form the IKS cardiac potassium current

…, F Lesage, E Guillemare, M Fink, M Lazdunski… - Nature, 1996 - nature.com
IN mammalian cardiac cells, a variety of transient or sustained K + currents contribute to the
repolarization of action potentials 1 . There are two main components of the delayed-rectifier …

TREK‐1, a K+ channel involved in neuroprotection and general anesthesia

…, M Zanzouri, G Romey, M Lazdunski - The EMBO …, 2004 - embopress.org
TREK‐1 is a two‐pore‐domain background potassium channel expressed throughout the
central nervous system. It is opened by polyunsaturated fatty acids and lysophospholipids. It is …

Inhalational anesthetics activate two-pore-domain background K+ channels

…, F Lesage, M Fink, G Romey, M Lazdunski - Nature …, 1999 - nature.com
Volatile anesthetics produce safe, reversible unconsciousness, amnesia and analgesia via
hyperpolarization of mammalian neurons. In molluscan pacemaker neurons, they activate an …

[HTML][HTML] TASK, a human background K+ channel to sense external pH variations near physiological pH

…, M Fink, R Reyes, C Heurteaux, M Lazdunski - The EMBO …, 1997 - embopress.org
TASK is a new member of the recently recognized TWIK K+ channel family. This 395 amino
acid polypeptide has four transmembrane segments and two P domains. In adult human, …

[HTML][HTML] A mammalian two pore domain mechano‐gated S‐like K+ channel

…, F Lesage, M Fink, F Duprat, M Lazdunski - The EMBO …, 1998 - embopress.org
Aplysia S‐type K+ channels of sensory neurons play a dominant role in presynaptic
facilitation and behavioural sensitization. They are closed by serotonin via cAMP‐dependent …

Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channel.

…, R Reyes, G Romey, C Heurteaux, M Lazdunski - The EMBO …, 1996 - embopress.org
Human TWIK‐1, which has been cloned recently, is a new structural type of weak inward
rectifier K+ channel. Here we report the structural and functional properties of TREK‐1, a …

TWIK‐1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure.

…, E Guillemare, M Fink, F Duprat, M Lazdunski… - The EMBO …, 1996 - embopress.org
A new human weakly inward rectifying K+ channel, TWIK‐1, has been isolated. This channel
is 336 amino acids long and has four transmembrane domains. Unlike other mammalian K…