User profiles for M Lazdunski
michel lazdunskiProfesseur,Institute Molecular Pharmacology,CNRS,UCA,Nice-Sophia Antipolis Verified email at ipmc.cnrs.fr Cited by 84359 |
A proton-gated cation channel involved in acid-sensing
…, F Bassilana, C Heurteaux, M Lazdunski - Nature, 1997 - nature.com
… & Lazdunski, M. The nammalian degenerin MDEG, an amiloride-sensitive cation channel …
& Lazdunski, M. Functional degenerin-containing chimeras identify residues essential for …
& Lazdunski, M. Functional degenerin-containing chimeras identify residues essential for …
International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels
Potassium-selective channels are the largest and most diverse group of ion channels,
represented by some 70 known loci in the mammalian genome. The first cloned potassium …
represented by some 70 known loci in the mammalian genome. The first cloned potassium …
Molecular and functional properties of two-pore-domain potassium channels
F Lesage, M Lazdunski - American Journal of Physiology …, 2000 - journals.physiology.org
The two-pore-domain K + channels, or K 2P channels, constitute a novel class of K + channel
subunits. They have four transmembrane segments and are active as dimers. The tissue …
subunits. They have four transmembrane segments and are active as dimers. The tissue …
KvLQT1 and IsK (minK) proteins associate to form the IKS cardiac potassium current
…, F Lesage, E Guillemare, M Fink, M Lazdunski… - Nature, 1996 - nature.com
IN mammalian cardiac cells, a variety of transient or sustained K + currents contribute to the
repolarization of action potentials 1 . There are two main components of the delayed-rectifier …
repolarization of action potentials 1 . There are two main components of the delayed-rectifier …
TREK‐1, a K+ channel involved in neuroprotection and general anesthesia
…, M Zanzouri, G Romey, M Lazdunski - The EMBO …, 2004 - embopress.org
TREK‐1 is a two‐pore‐domain background potassium channel expressed throughout the
central nervous system. It is opened by polyunsaturated fatty acids and lysophospholipids. It is …
central nervous system. It is opened by polyunsaturated fatty acids and lysophospholipids. It is …
Inhalational anesthetics activate two-pore-domain background K+ channels
…, F Lesage, M Fink, G Romey, M Lazdunski - Nature …, 1999 - nature.com
Volatile anesthetics produce safe, reversible unconsciousness, amnesia and analgesia via
hyperpolarization of mammalian neurons. In molluscan pacemaker neurons, they activate an …
hyperpolarization of mammalian neurons. In molluscan pacemaker neurons, they activate an …
[HTML][HTML] TASK, a human background K+ channel to sense external pH variations near physiological pH
…, M Fink, R Reyes, C Heurteaux, M Lazdunski - The EMBO …, 1997 - embopress.org
TASK is a new member of the recently recognized TWIK K+ channel family. This 395 amino
acid polypeptide has four transmembrane segments and two P domains. In adult human, …
acid polypeptide has four transmembrane segments and two P domains. In adult human, …
[HTML][HTML] A mammalian two pore domain mechano‐gated S‐like K+ channel
Aplysia S‐type K+ channels of sensory neurons play a dominant role in presynaptic
facilitation and behavioural sensitization. They are closed by serotonin via cAMP‐dependent …
facilitation and behavioural sensitization. They are closed by serotonin via cAMP‐dependent …
Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channel.
…, R Reyes, G Romey, C Heurteaux, M Lazdunski - The EMBO …, 1996 - embopress.org
Human TWIK‐1, which has been cloned recently, is a new structural type of weak inward
rectifier K+ channel. Here we report the structural and functional properties of TREK‐1, a …
rectifier K+ channel. Here we report the structural and functional properties of TREK‐1, a …
TWIK‐1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure.
…, E Guillemare, M Fink, F Duprat, M Lazdunski… - The EMBO …, 1996 - embopress.org
A new human weakly inward rectifying K+ channel, TWIK‐1, has been isolated. This channel
is 336 amino acids long and has four transmembrane domains. Unlike other mammalian K…
is 336 amino acids long and has four transmembrane domains. Unlike other mammalian K…