Clathrin-mediated endocytosis is the primary pathway for receptor and cargo internalization
in eukaryotic cells. It is characterized by a polyhedral clathrin lattice that coats budding …

Background: Upon natural agonist or pharmacological stimulation, G protein-coupled receptors
(GPCRs) are subjected to posttranslational modifications, such as phosphorylation and …

Internalization of G protein-coupled receptors can be triggered by agonists or by other
stimuli. The process begins within seconds of cell activation and contributes to receptor …

The crosstalk between growth factor and adhesion receptors is key for cell growth and
migration. In pathological settings, these receptors are drivers of cancer. Yet, how growth and …

Human α 1D -adrenoceptors (α 1D -ARs) are a group of the seven transmembrane-spanning
proteins that mediate many of the physiological and pathophysiological actions of …

Upon agonist stimulation, α 1B -adrenergic receptors couple to G q proteins, calcium
signaling and protein kinase C activation; subsequently, the receptors are phosphorylated, …

In LNCaP cells that stably express α 1A -adrenergic receptors, oxymetazoline increased
intracellular calcium and receptor phosphorylation, however, this agonist was a weak partial …

The human α 1D -adrenergic receptor is a seven transmembrane-domain protein that mediates
many of the physiological actions of adrenaline and noradrenaline and participates in …

Phosphorylation of the human α 1B -adrenergic receptor (fused with the green fluorescent
protein) was studied employing the inducible Flp-ln HEK293 T-Rex system for expression. …

Clathrin mediated endocytosis is the primary pathway for receptor and cargo internalization
in eukaryotic cells. It is characterized by a polyhedral clathrin lattice that coats budding …