Objective— The ability of the potent cholesteryl ester transfer protein (CETP) inhibitor
torcetrapib (CP-529,414) to raise high-density lipoprotein cholesterol (HDL-C) levels in healthy …

The unimolecular dissociation rate constant, k −1 , for the inhibitor-enzyme complex
tubercidin-Escherichia coli purine nucleoside phosphorylase (PNPase) has been determined …

The mechanism by which preconditioning (brief intermittent periods of ischemia and reflow)
improves recovery of function and reduces enzyme release after a subsequent 30-minute …

Torcetrapib is a highly lipophilic (ClogP=7.45) and water insoluble cholesteryl ester transfer
protein (CETP) inhibitor developed for the treatment of atherosclerosis. Self-emulsifying drug …

In the present investigation, the rationale for the design, synthesis, and biological evaluation
of potent inhibitors of neuronal Na + channels is described. N,N‘-Diaryl- and N-aryl-N-…

The synthesis of l-(2-deoxy-2-fluoro-dD-arabinofuranosyl) cytosines with a halovinyl (8 and
9) or vinyl (10) substituent at C-5 was accomplished from the corresponding 5-iodo (FIAC, 1) …

Synthesis and structure−activity relationships (SAR) are described for a series of N,N‘-diarylguanidines
related to N-acenaphth-5-yl-N‘-(4-methoxynaphth-1-yl)guanidine (3) as …

N-(1-Naphthyl)-N′-(3-[ 125 I]-iodophenyl)-N′-methylguanidine ([ 125 I]-CNS 1261) was
synthesized as a potential radioligand to image N-methyl-D-aspartate (NMDA) receptor …

A matrix formalism is developed for calculations of time-dependent nuclear Overhauser
effects in systems undergoing chemical exchange, and the analysis is applied to the …

A revised crystallization process for TAK-117, a selective PI3Kα inhibitor currently in Phase
1b clinical trials, was developed that greatly improved the overall purity, recovery, and …