Tauopathies are neurodegenerative diseases that are characterized by accumulation of
hyperphosphorylated tau protein, higher-order aggregates, and tau filaments. Protein …

We showed previously that OX 1 orexin receptor stimulation produced a strong 3 H overflow
response from [ 3 H]arachidonic acid (AA)-labeled cells. Here we addressed this issue with …

Human OX 1 orexin receptors have been shown to homodimerize and they have also been
suggested to heterodimerize with CB 1 cannabinoid receptors. The latter has been …

BACKGROUND AND PURPOSE Orexin receptors potently signal to lipid messenger
systems, and our previous studies have suggested that PLD would be one of these. We thus …

Key Takeaways• Without a valid, reliable way to collect data from various library and
enterprise systems, it's difficult to quantitatively assert how a library adds value.• University of …

It has been proposed that OX 1 orexin receptors and CB 1 cannabinoid receptors can form
heteromeric complexes, which affect the trafficking of OX 1 receptors and potentiate OX 1 …

Despite the recent successes in producing orexin receptor subtype-selective antagonists,
these are not commonly available, and therefore, agonist ligands are regularly used to ascribe …

In a period of economic turmoil, resource scarcity, and increased competitiveness in the
attraction and retention of students, the ability to demonstrate the value gained by utilising library …

Protein kinase C (PKC) isoforms play a pivotal role in the regulation of numerous cellular
functions, making them extensively studied and highly attractive drug targets. Utilizing the …

The guidance of developing neurons to the right position in the central nervous system is of
central importance in brain development. Canonical transient receptor potential (TRPC) …