Ryanodine receptors (RyR) are intracellular Ca 2+ -permeable channels that provide the
sarcoplasmic reticulum Ca 2+ release required for skeletal and cardiac muscle contractions. …

Great insight has been gained into the structure and function of the inositol 1,4,5 trisphosphate
receptor (InsP 3 R) by studies employing mutagenesis of the cDNA encoding the receptor…

Age-related loss of muscle mass and force (sarcopenia) contributes to disability and increased
mortality. Ryanodine receptor 1 (RyR1) is the skeletal muscle sarcoplasmic reticulum …

Increased sarcoplasmic reticulum (SR) Ca 2+ leak via the cardiac ryanodine receptor/calcium
release channel (RyR2) is thought to play a role in heart failure (HF) progression. …

Background : BrS is an inherited sudden cardiac death syndrome. Less than 35% of BrS
probands have genetically identified pathogenic variants. Recent evidence has implicated …

During the classic “fight-or-flight” stress response, sympathetic nervous system activation
leads to catecholamine release, which increases heart rate and contractility, resulting in …

The type 2 ryanodine receptor/calcium release channel (RyR2), required for excitation-contraction
coupling in the heart, is abundant in the brain. Chronic stress induces catecholamine …

Ryanodine receptors (RyR) regulate intracellular Ca 2+ release in many cell types and
have been implicated in a number of inherited human diseases. Over the past 15years …

The force frequency relationship (FFR), first described by Bowditch 139 years ago as the
observation that myocardial contractility increases proportionally with increasing heart rate, is …

Background Disruption of the sarcolemma-associated dystrophin-glycoprotein complex
underlies multiple forms of muscular dystrophy, including Duchenne muscular dystrophy and …