Lipoproteins are endogenous particles that transport lipids through the blood to various cell
types, where they are recognised and taken up via specific receptors. These particles are, …

Hepatitis B virus (HBV) infection is the world's most important chronic virus infection. No safe
and effective treatment is available at present, and clinical exploration of promising antiviral …

Systemically administered phosphorothioate antisense oligodeoxynucleotides can specifically
affect the expression of their target genes, which affords an exciting new strategy for …

A series of glycolipids have been prepared which contain a cluster galactoside moiety with
high affinity for the hepatic asialoglycoprotein receptor and a bile acid ester moiety which …

Several studies have shown improved efficacy of cholesteryl-conjugated phosphorothioate
antisense oligodeoxynucleotides. To gain insight into the mechanisms of the improved …

Anti-sense oligodeoxynucleotides (ODNs) hold great promise for correcting the biosynthesis
of clinically relevant proteins. The potential of ODNs for modulating liver-specific genes …

… This article is dedicated to the memory of Martin Bijsterbosch, an active and respected
member of the scientific community, who passed away on May 9, 2003, at the age of 49. …

Resting B lymphocytes can be activated and induced to proliferate by antibodies against
their antigen receptors (anti-Ig). We demonstrate an early increase in the level of [3H]inositol …

F(ab')2 fragments of rabbit anti-mouse Ig induce proliferation of murine B lymphocytes, whereas
the intact antibodies are not mitogenic. F(ab')2 anti-Ig stimulates the rapid breakdown of …

Recently it was found that lactoferrin, an iron-binding glycoprotein with a molecular weight
of 76,500, inhibits the remnant receptor-mediated uptake of apolipoprotein E (apoE)-bearing …