Background: Laparoscopic cholecystectomy has advantages over the open procedure for
postoperative pain. However, a systematic review of postoperative pain management in this …

The antinociception induced by the intraperitoneal coadministration of combinations of
paracetamol with the nonsteroidal anti-inflammatory drugs (NSAIDs) diclofenac, ibuprofen, …

Background Opioid-induced delayed hyperalgesia and allodynia have been reported in human
and animal models. The authors evaluated the influence of different opioids used during …

The effect of two commonly used methods to immobilize the animals, viz. tube restrainer and
wrapping in a diaper (chux) on the tail flick latency in immersion test, was evaluated in mice …

Objectives Unrelieved pain is a substantial public health concern necessitating improvements
in medical education. The Advancing the Provision of Pain Education and Learning (…

Background Remifentanil anesthesia enhances postoperative pain in animals and humans.
The authors evaluated the impact of the dose (microg x kg(-1) x min(-1)) and duration of …

Background About 240 million patients undergo surgery every year, worldwide. Roughly 50%
of these patients report clinically significant pain. Numerous barriers impede provision of …

The long-lasting post-surgical changes in nociceptive thresholds in mice, indicative of latent
pain sensitization, were studied. The contribution of kappa opioid and N-methyl-d-aspartate (…

In mice with streptozotocin-induced hyperglycemia, nociception was tested after naloxone
administration in hot plate and tail immersion tests. The choice of these two tests was to …

Pain after surgery remains a problem worldwide, although there are no published data on
postoperative outcomes in Spain. We evaluated 2,922 patients on the first day after surgery in …