… Valente contributed equally in the conception and drafting of the manuscript. … Copyright ©
2014 Bellini, Pavesi, Barbiero, Bergo, Chandola, Nawaz, Rusconi, Stefanelli, Strollo, Valente, …

Personalized treatments and predictive biomarkers of pancreatic cancer (PDAC) are still
lacking. Recently germline mutations in BRCA 1 and 2 genes, leading to homologous repair …

… Under these experimental conditions, we tested the effects of ALC (0.01–1 mM). The drug
significantly increased, in a concentration-dependent manner, the percentage of MAP-2 + cells …

Although the role of adult hippocampal neurogenesis remains to be fully elucidated, several
studies suggested that the process is involved in cognitive and emotional functions and is …

Mutations in MECP 2 cause several neurological disorders of which Rett syndrome ( RTT )
represents the best‐defined condition. Although mainly working as a transcriptional repressor…

… After 48 h, cells were harvested and resuspended with 100 μl of a solution containing 10
mM Tris-HCl pH 7.4, 1 mM EDTA. The samples were then lysed with an equal volume of 2% …

Objective Germline BRCA1-2 pathogenic variants (gBRCApv) increase the risk of pancreatic
cancer and predict for response to platinating agents and poly(ADP-ribose) polymerase …

Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that play a role in
varied forms of developmental and postnatal neuroplasticity. MMP substrates include protease-…

Hepatocyte nuclear factor 4 α (HNF4α), a transcription factor (TF) essential for embryonic
development, has been recently shown to regulate the expression of inflammatory genes. To …

Background Germline BRCA1-2 pathogenic variants (gBRCA1-2pv)-related pancreatic ductal
adenocarcinoma (PDAC) showed increased sensitivity to DNA cross-linking agents. This …