Mislocated enzymatic activity of DOT1L has been proposed as a driver of leukemogenesis
in mixed lineage leukemia (MLL). The characterization of EPZ004777, a potent, selective …

EZH2 catalyzes trimethylation of histone H3 lysine 27 (H3K27). Point mutations of EZH2 at
Tyr641 and Ala677 occur in subpopulations of non-Hodgkin's lymphoma, where they drive …

Mutations in the adenomatous polyposis coli or β-catenin gene lead to cytosolic accumulation
of β-catenin and, subsequently, to increased transcriptional activity of the β-catenin–T cell-…

The epidermal growth factor receptor (EGFR) is overexpressed in a significant percentage
of carcinomas and contributes to the malignant phenotype. CP-358,774 is a directly acting …

Rearrangements of the MLL gene define a genetically distinct subset of acute leukemias
with poor prognosis. Current treatment options are of limited effectiveness; thus, there is a …

Inactivation of the switch/sucrose nonfermentable complex component SMARCB1 is extremely
prevalent in pediatric malignant rhabdoid tumors (MRTs) or atypical teratoid rhabdoid …

Protein arginine methyltransferase-5 (PRMT5) is reported to have a role in diverse cellular
processes, including tumorigenesis, and its overexpression is observed in cell lines and …

Background & Aims Nearly 20% of the global cancer burden can be linked to infectious
agents. Fusobacterium nucleatum promotes tumor formation by epithelial cells via unclear …

Mutations within the catalytic domain of the histone methyltransferase EZH2 have been
identified in subsets of patients with non-Hodgkin lymphoma (NHL). These genetic alterations …

Commercially prepared grape (Vitis vinifera), bilberry (Vaccinium myrtillus L.), and chokeberry
(Aronia meloncarpa E.) anthocyanin-rich extracts (AREs) were investigated for their …