Endothelial dysfunction in diabetes: from mechanisms to therapeutic targets

…, S Gagliardi, C Nacci, MR Carratu… - Current medicinal …, 2009 - ingentaconnect.com
Micro- and macrovascular complications are major causes of disability and death in patients
with diabetes mellitus. Functional impairment of endothelial activity precedes the …

Therapeutic targeting of the mTOR‐signalling pathway in cancer: benefits and limitations

…, C Marasco, A Vacca, MR Carratù - British journal of …, 2014 - Wiley Online Library
The mammalian target of rapamycin ( mTOR ) plays an important role in the regulation of
protein translation, cell growth and metabolism. The mTOR protein forms two distinct multi‐…

[HTML][HTML] Cannabidiol reduces Aβ-induced neuroinflammation and promotes hippocampal neurogenesis through PPARγ involvement

…, V Latina, D De Filippis, M Cipriano, MR Carratù… - PloS one, 2011 - journals.plos.org
Peroxisome proliferator-activated receptor-γ (PPARγ) has been reported to be involved in
the etiology of pathological features of Alzheimer's disease (AD). Cannabidiol (CBD), a …

Synergistic effects of fumonisin B1 and ochratoxin A: are in vitro cytotoxicity data predictive of in vivo acute toxicity?

…, I Baudrimont, P Borracci, S Moukha, MR Carratù - Toxicology, 2004 - Elsevier
Contamination of food and feeds by mycotoxins is a major problem of human and animals
health concern which is also extremely detrimental to economy. Mycotoxins producing moulds …

Effects of perinatal exposure to delta-9-tetrahydrocannabinol on the emotional reactivity of the offspring: a longitudinal behavioral study in Wistar rats

…, T Cassano, T Macheda, P Dipasquale, MR Carratù… - …, 2008 - Springer
Rationale The endocannabinoid system plays a crucial role in the control of emotionality
and recent clinical findings have shown that heavy prenatal exposure to cannabis is …

[HTML][HTML] Emerging roles for ion channels in ovarian cancer: Pathomechanisms and pharmacological treatment

C Altamura, MR Greco, MR Carratù, RA Cardone… - Cancers, 2021 - mdpi.com
Simple Summary Around 4% of cancer deaths in the world was associated to ovarian cancer
(OC), making it the eighth most common cause of death in women. Increasing evidence …

[HTML][HTML] Palmitoylethanolamide exerts neuroprotective effects in mixed neuroglial cultures and organotypic hippocampal slices via peroxisome proliferator-activated …

…, M Valenza, C Stecca, G Esposito, MR Carratù… - Journal of …, 2012 - Springer
Background In addition to cytotoxic mechanisms directly impacting neurons, β-amyloid (Aβ)-induced
glial activation also promotes release of proinflammatory molecules that may self-…

Epigenetic properties of fumonisin B1: cell cycle arrest and DNA base modification in C6 glioma cells

TA Mobio, R Anane, I Baudrimont, MR Carratú… - Toxicology and applied …, 2000 - Elsevier
Fumonisin B 1 produced by the fungus Fusarium moniliforme is a member of a new class of
sphinganine analogue mycotoxins that occur widely in the food chain. Epidemiological …

Endothelial dysfunction in mice with streptozotocin-induced type 1 diabetes is opposed by compensatory overexpression of cyclooxygenase-2 in the vasculature

…, A Mauro, A Zigrino, MR Carratu… - …, 2009 - academic.oup.com
Cardiovascular complications of diabetes result from endothelial dysfunction secondary to
persistent hyperglycemia. We investigated potential compensatory mechanisms in the …

[HTML][HTML] A silybin-phospholipids complex counteracts rat fatty liver degeneration and mitochondrial oxidative changes

…, A Liquori, D Ferri, MR Carratù… - World Journal of …, 2013 - ncbi.nlm.nih.gov
AIM: To investigate the effectiveness of antioxidant compounds in modulating mitochondrial
oxidative alterations and lipids accumulation in fatty hepatocytes. METHODS: Silybin-…