Macitentan, also called Actelion-1 or ACT-064992 [N-[5-(4-bromophenyl)-6-(2-(5-bromopyrimidin-2-yloxy)ethoxy)-pyrimidin-4-yl]-N′-propylaminosulfonamide],
is a new dual ET A /ET …

Objective: To obtain precise information on the optimal time window for surgical antimicrobial
prophylaxis. Summary Background Data: Although perioperative antimicrobial prophylaxis …

Background: Why did Nature choose furanosyl-RNA and not pyranosyl-RNA as her molecular
genetic system? An experimental approach to this problem is the systematic comparison …

… YOhashi M Unnoticed glove perforation during thoracoscopic and open thoracic surgery. …
YOhashi M Unnoticed glove perforation during thoracoscopic and open thoracic surgery. …

Objective Tumour-infiltrating lymphocytes (TILs) favour survival in human colorectal cancer (CRC).
Chemotactic factors underlying their recruitment remain undefined. We investigated …

Sphingosine-1-phosphate (S1P) is a widespread lysophospholipid which displays a wealth
of biological effects. Extracellular S1P conveys its activity through five specific G-protein …

Starting from the structure of bosentan (1), we embarked on a medicinal chemistry program
aiming at the identification of novel potent dual endothelin receptor antagonists with high oral …

Purpose: Tumor infiltration by different T lymphocyte subsets is known to be associated with
favorable prognosis in colorectal cancer. Still debated is the role of innate immune system. …

… or sorted cells using the RNeasy Mini Kit protocol (Qiagen), treated with DNAse I (Invitrogen)
and reverse transcribed using the Moloney murine leukemia virus reverse transcriptase (M-…

Plasma cells (PCs) are terminally differentiated cells of the B-cell lineage that secrete antibodies
at a high rate and are thought to lack the expression of the B-cell receptor (BCR). Here, …