1, 2, 3-Triazole-[2, 5-Bis-O-(tert-butyldimethylsilyl)-. beta.-D-ribofuranosyl]-3'-spiro-5''-(4''-amino-1'', 2''-oxathiole 2'', 2''-dioxide)(TSAO) Analogs: Synthesis and Anti-HIV …
…, A Karlsson, J Balzarini, MJ Camarasa - Journal of medicinal …, 1994 - ACS Publications
… When exposed to 1.5 /¿M 16, that is, at a 10-fold higher concentration than its EC50 value,
resistant virus breakthrough occurred at the third subcultivation (day 10 of the experiment) …
resistant virus breakthrough occurred at the third subcultivation (day 10 of the experiment) …
Efficacy of aminocaproic, tranexamic acids in the control of bleeding during total knee replacement: a randomized clinical trial
MA Camarasa, G Ollé, M Serra-Prat… - BJA: British Journal …, 2006 - academic.oup.com
Background. Risks and costs of allogeneic blood transfusions mandate strategies to reduce
blood loss in surgery. The objective of this study was to assess the efficacy of antifibrinolytic …
blood loss in surgery. The objective of this study was to assess the efficacy of antifibrinolytic …
Regiospecific Synthesis and Anti-Human Immunodeficiency Virus Activity of Novel 5-Substituted N-Alkylcarbamoyl and N,N-Dialkyl Carbamoyl 1,2,3-Triazole-TSAO …
…, J Balzarini, MJ Camarasa - Antiviral Chemistry …, 1998 - journals.sagepub.com
Several 5-N-alkyl and 5-N,N-dialkylcarbamoyl substituted analogues of the anti-human
immunodeficiency virus (HIV) type 1 lead compound[1-[2‘,5’-bis-O-(tert-butyldimethylsilyl)-β-D-…
immunodeficiency virus (HIV) type 1 lead compound[1-[2‘,5’-bis-O-(tert-butyldimethylsilyl)-β-D-…
[HTML][HTML] Polypharmacology in HIV inhibition: can a drug with simultaneous action against two relevant targets be an alternative to combination therapy?
S de Castro, MJ Camarasa - European journal of medicinal chemistry, 2018 - Elsevier
… Conjugates of an HIV-1 RT NRTI and an NNRTI were first reported by the Camarasa’s
group [10]. The authors prepared different hybrids that combined in a single molecule an NRTI …
group [10]. The authors prepared different hybrids that combined in a single molecule an NRTI …
Thymidine phosphorylase inhibitors: recent developments and potential therapeutic applications
…, AI Hernández, MJ Camarasa… - Mini reviews in …, 2005 - ingentaconnect.com
Thymidine Phosphorylase (TPase) catalyses the reversible phosphorolysis of pyrimidine 2'-
deoxynucleosides to 2-deoxyribose-1-phosphate and their respective pyrimidine bases, …
deoxynucleosides to 2-deoxyribose-1-phosphate and their respective pyrimidine bases, …
Dimerization inhibitors of HIV-1 reverse transcriptase, protease and integrase: a single mode of inhibition for the three HIV enzymes?
The genome of human immunodeficiency virus type 1 (HIV-1) encodes 15 distinct proteins,
three of which provide essential enzymatic functions: a reverse transcriptase (RT), an …
three of which provide essential enzymatic functions: a reverse transcriptase (RT), an …
2', 5'-Bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'', 2''-oxathiole-2'', 2'-dioxide) pyrimidine (TSAO) nucleoside analogues: highlyselective inhibitors of human …
…, AM Vandamme, MJ Camarasa… - Proceedings of the …, 1992 - National Acad Sciences
… blot analysis) at 10,ug/ml(16.9 and 16.6 ,uM, respectively) in infected MT-4 cells, whereas
AZT achieved 99.9o inhibition of proviral DNA formation at a concentration of 0.4 ,g/ml (1.5 ,M). …
AZT achieved 99.9o inhibition of proviral DNA formation at a concentration of 0.4 ,g/ml (1.5 ,M). …
3'-Spiro nucleosides, a new class of specific human immunodeficiency virus type 1 inhibitors: synthesis and antiviral activity of [2', 5'-bis-O-(tert-butyldimethylsilyl) …
MJ Camarasa, MJ Perez-Perez… - Journal of Medicinal …, 1992 - ACS Publications
… M. Pyridinone derivatives: specific human immunodeficiency virus type 1 reverse
transcriptase inhibitors with antiviral activity. Proc. … M. J.; Tronchet, JF Synthese et …
transcriptase inhibitors with antiviral activity. Proc. … M. J.; Tronchet, JF Synthese et …
Identification of [1,2,3]Triazolo[4,5-d]pyrimidin-7(6H)-ones as Novel Inhibitors of Chikungunya Virus Replication
…, L Delang, EM Priego, MJ Camarasa… - Journal of Medicinal …, 2014 - ACS Publications
… the triazolo derivatives 10a–m. Finally, treatment of 10a–m with sodium acetate in DMF
afforded the [1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones 11a–m. Saponification of the ethyl ester …
afforded the [1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones 11a–m. Saponification of the ethyl ester …
Tri-, tetra-and heptacyclic perylene analogues as new potential antineoplastic agents based on DNA telomerase inhibition
…, DJ Maloney, MB Boxer, MV Camarasa… - Bioorganic & medicinal …, 2007 - Elsevier
A recent approach in anticancer chemotherapy envisages telomerase as a potentially useful
target. An attractive strategy deals with the development of compounds able to stabilize …
target. An attractive strategy deals with the development of compounds able to stabilize …