Evolutionary theories are critical for understanding cancer development at the level of species
as well as at the level of cells and tissues, and for developing effective therapies. Animals …

The incidence of cancer is higher in the elderly; however, many of the underlying mechanisms
for this association remain unexplored. Here, we have shown that B cell progenitors in old …

Lung cancer is the leading cause of death worldwide. Adenocarcinomas, the most common
histologic subtype of non-small cell lung cancer (NSCLC), are frequently associated with …

An association between lymph node metastasis and poor prognosis in breast cancer was
observed decades ago. However, the mechanisms by which tumor cells infiltrate the lymphatic …

Purpose: The emergence of EGFR inhibitors such as gefitinib, erlotinib, and osimertinib has
provided novel treatment opportunities in EGFR-driven non–small cell lung cancer (NSCLC)…

While dietary folate deficiency is associated with increased risk for birth defects and other
diseases, evidence suggests that supplementation with folic acid can contribute to …

Exposure to ionizing radiation and other DNA-damaging carcinogens is strongly associated
with induction of malignancies. Prevailing paradigms attribute this association to the …

Our laboratory has previously shown that some gefitinib-insensitive head and neck squamous
cell carcinoma (HNSCC) cell lines exhibit dominant autocrine fibroblast growth factor …

Wnt signaling is critical for development, cell proliferation and differentiation, and mutations
in this pathway resulting in constitutive signaling have been implicated in various cancers. A …

The front cover picture shows the process of photocrosslinking a small molecule functionalized
with a diaziridino group to its putative target upon UV irradiation, a critical step in …