Principles for the post-GWAS functional characterization of cancer risk loci

…, M De Biasi, C Carlson, D Duggan, M James… - Nature …, 2011 - nature.com
1 Nature America, Inc. All rights reserv ed. perspective 514 volume 43| number 6| june 2011|
NATURE GENETICS region if a similar association was found in this population, as the …

Cellular mechanisms of nicotine addiction

JA Dani, M De Biasi - Pharmacology Biochemistry and Behavior, 2001 - Elsevier
In developed countries, tobacco use is estimated to be the largest single cause of premature
death [Lancet 339 (1992) 1268]. Nicotine is the main addictive component of tobacco that …

Reward, addiction, withdrawal to nicotine

M De Biasi, JA Dani - Annual review of neuroscience, 2011 - annualreviews.org
Nicotine is the principal addictive component that drives continued tobacco use despite
users' knowledge of the harmful consequences. The initiation of addiction involves the …

Mice deficient in the α7 neuronal nicotinic acetylcholine receptor lack α-bungarotoxin binding sites and hippocampal fast nicotinic currents

…, I Lorenzo, L Goldberg, M De Biasi… - Journal of …, 1997 - Soc Neuroscience
The α7 subunit of the neuronal nicotinic acetylcholine receptor (nAChR) is abundantly
expressed in hippocampus and is implicated in modulating neurotransmitter release and in …

Nicotine decreases food intake through activation of POMC neurons

…, RJ DiLeone, D Gündisch, S Diano, M De Biasi… - Science, 2011 - science.org
Smoking decreases appetite, and smokers often report that they smoke to control their
weight. Understanding the neurobiological mechanisms underlying the anorexic effects of …

Nicotinic receptors in the habenulo-interpeduncular system are necessary for nicotine withdrawal in mice

…, R Sturm, J Boulter, M De Biasi - Journal of Neuroscience, 2009 - Soc Neuroscience
In humans, tobacco withdrawal produces symptoms that contribute to the difficulty associated
with smoking cessation. Nicotine withdrawal symptoms can also be observed in rodents. A …

Multiorgan autonomic dysfunction in mice lacking the β2 and the β4 subunits of neuronal nicotinic acetylcholine receptors

…, LW Role, AL Beaudet, M De Biasi - Journal of …, 1999 - Soc Neuroscience
… recording solution consisting of 150 mm NaCl, 3 mm KCl, 2.5 mm CaCl 2 , 10 mm glucose,
10 mm HEPES, and 1 μm tetrodotoxin, titrated to pH 7.2 with 1 mNaOH. The culture dish was …

Megacystis, mydriasis, and ion channel defect in mice lacking the α3 neuronal nicotinic acetylcholine receptor

…, CN Ou, J Patrick, L Role, M De Biasi… - Proceedings of the …, 1999 - National Acad Sciences
… For dose responses to CCH, drug was added in cumulative doses from 10 −7 M to 3 × 10
−4 M after incubating the strips with 20 μM hexamethonium chloride for 20 … Mariella De Biasi

Decreased signs of nicotine withdrawal in mice null for the β4 nicotinic acetylcholine receptor subunit

R Salas, F Pieri, M De Biasi - Journal of Neuroscience, 2004 - Soc Neuroscience
Withdrawal from chronic exposure to nicotine, the main addictive component of tobacco,
produces distinctive symptoms in humans. The appearance of these symptoms is a major …

Evaluating the suitability of nicotinic acetylcholine receptor antibodies for standard immunodetection procedures

…, JP Bourgeois, AM Le Sourd, M De Biasi… - Journal of …, 2007 - Wiley Online Library
Nicotinic acetylcholine receptors play important roles in numerous cognitive processes as
well as in several debilitating central nervous system (CNS) disorders. In order to fully …