Cell-specific delivery of genes with glycosylated carriers

M Hashida, M Nishikawa, F Yamashita… - Advanced drug delivery …, 2001 - Elsevier
Cationic liposomes and polymers have been accepted as effective non-viral vectors for gene
delivery with low immunogenicity unlike viral vectors. However, the lack of organ or cell …

Macromolecular carrier systems for targeted drug delivery: pharmacokinetic considerations on biodistribution

Y Takakura, M Hashida - Pharmaceutical research, 1996 - Springer
… Takakura and M. Hashida. Improvement of therapeutic effect of human recombinant superoxide
dismutase on ischemic acute renal failure in the rat via cationization and conjugation …

Catalase delivery for inhibiting ROS-mediated tissue injury and tumor metastasis

M Nishikawa, M Hashida, Y Takakura - Advanced drug delivery reviews, 2009 - Elsevier
Reactive oxygen species (ROS) have been suggested to be involved in a variety of human
diseases. Catalase, an enzyme degrading hydrogen peroxide, can be used as a therapeutic …

The fate of plasmid DNA after intravenous injection in mice: involvement of scavenger receptors in its hepatic uptake

K Kawabata, Y Takakura, M Hashida - Pharmaceutical research, 1995 - Springer
… Sezaki, and M. Hashida. Therapeutic effects of superoxide dismutase derivatives modified
with mono- and polysaccharide on hepatic injury induced by ischemia/reperfusion. Biochem. …

Mannose receptor-mediated gene transfer into macrophages using novel mannosylated cationic liposomes

…, A Sato, M Nishikawa, F Yamashita, M Hashida - Gene therapy, 2000 - nature.com
A novel mannosylated cholesterol derivative, cholesten-5-yloxy-N-(4-((1-imino-2-β-D-thiomannosyl-ethyl)
amino) butyl) formamide (Man-C4-Chol), was synthesized in order to perform …

Mechanism for self-formation of periodic grating structures on a metal surface by a femtosecond laser pulse

S Sakabe, M Hashida, S Tokita, S Namba, K Okamuro - Physical Review B, 2009 - APS
… The laser pulse cannot propagate to depths beyond the point where n =m 2/4 e2 n is the
electron density, e is the electron charge, and m is the electron mass. On the other hand, for …

Defective stratum corneum and early neonatal death in mice lacking the gene for transglutaminase 1 (keratinocyte transglutaminase)

…, M Hashida, H Iizuka, M Ikawa… - Proceedings of the …, 1998 - National Acad Sciences
The stratum corneum of the skin serves as an effective barrier for maintenance of the internal
milieu against the external environment. At the cell periphery of the stratum corneum is the …

The 4F2hc/LAT1 complex transports L-DOPA across the blood–brain barrier

…, Y Takakura, M Hashida, Y Kanai, M Naito… - Brain research, 2000 - Elsevier
… The cells were lysed with 0.3 M NaOH containing 0.1% Triton-X and the radioactivity of the
lysate was measured by liquid scintillation counting. The protein content was determined by …

In vitro cytotoxicity of macromolecules in different cell culture systems

…, S Masuda, H Tokuda, Y Takakura, M Hashida - Journal of Controlled …, 1995 - Elsevier
… Sezaki and M. Hashida, Pharmacokinetics of succinylated proteins and dextran sulfate in
mice: implications for hepatic targeting of protein drugs by direct succinylation via scavenger …

Liquid-cooled 24 W mid-infrared Er: ZBLAN fiber laser

S Tokita, M Murakami, S Shimizu, M Hashida… - Optics letters, 2009 - opg.optica.org
… A 24 W liquid-cooled CW 3 μ m fiber laser with a multimode-core Er-doped ZBLAN fiber
has … To our knowledge, this is the highest output power obtained by a 3 μ m fiber laser. …