PTC124 targets genetic disorders caused by nonsense mutations

…, VJ Northcutt, LL Miller, P Spatrick, F He, M Kawana… - Nature, 2007 - nature.com
Nonsense mutations promote premature translational termination and cause anywhere from
5–70% of the individual cases of most inherited diseases 1 . Studies on nonsense-mediated …

Effects of hypertrophic and dilated cardiomyopathy mutations on power output by human β-cardiac myosin

…, SR Bartholomew, S Nag, M Kawana… - Journal of …, 2016 - journals.biologists.com
Hypertrophic cardiomyopathy is the most frequently occurring inherited cardiovascular disease,
with a prevalence of more than one in 500 individuals worldwide. Genetically acquired …

Acute decompensated heart failure syndromes (ATTEND) registry. A prospective observational multicenter cohort study: rationale, design, and preliminary data

…, R Muanakata, D Yumino, T Meguro, M Kawana… - American heart …, 2010 - Elsevier
Acute heart failure syndromes (AHFS) are likely to increase in the future, and the high
readmission rate of patients with AHFS is an important issue in Western countries. However, there …

[HTML][HTML] Hypertrophic cardiomyopathy: mutations to mechanisms to therapies

M Kawana, JA Spudich, KM Ruppel - Frontiers in Physiology, 2022 - frontiersin.org
Hypertrophic cardiomyopathy (HCM) affects more than 1 in 500 people in the general
population with an extensive burden of morbidity in the form of arrhythmia, heart failure, and …

[HTML][HTML] Angiographic findings and surgical treatments of coronary artery involvement in Takayasu arteritis

…, S Aomi, M Nakazawa, Y Tsurumi, M Kawana… - The Journal of Thoracic …, 2003 - Elsevier
Background: Takayasu arteritis is associated with a low incidence of coronary artery involvement,
such as stenosis, obstruction, aneurysm, and coronary steal syndrome, but coronary …

Cloning and characterization of developmental endothelial locus-1: an embryonic endothelial cell protein that binds the αvβ3 integrin receptor

…, T Zupancic, K Penta, A Mikhail, M Kawana… - Genes & …, 1998 - genesdev.cshlp.org
… Insoluble inclusion bodies were collected by centrifugation and dissolved in 8m urea, 50
mm Tris-Cl (pH 8.0), 0.5 mEDTA, and 100 mm DTT for 2 hr at room temperature. Recombinant …

Endogenous regulation of cardiovascular function by apelin-APJ

…, M Ho, G Fajardo, M Kawana… - American Journal …, 2009 - journals.physiology.org
Studies have shown significant cardiovascular effects of exogenous apelin administration,
including the potent activation of cardiac contraction. However, the role of the endogenous …

Clinical potential of intravascular ultrasound for physiological assessment of coronary stenosis: relationship between quantitative ultrasound tomography and pressure …

A Takagi, Y Tsurumi, Y Ishii, K Suzuki, M Kawana… - Circulation, 1999 - Am Heart Assoc
Background—Little is known regarding intravascular ultrasound (IVUS) criteria to determine
the functional severity of coronary stenosis. Recently, fractional flow reserve (FFR) has …

[HTML][HTML] DOCK2 is involved in the host genetics and biology of severe COVID-19

…, S Arai, Y Kaneko, K Sasaki, E Tagaya, M Kawana… - Nature, 2022 - nature.com
Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge 1
, 2 , 3 , 4 – 5 . Here we conducted a genome-wide association study (GWAS) involving 2,393 …

Clinical implications of midventricular obstruction in patients with hypertrophic cardiomyopathy

…, S Haruki, T Nakajima, N Kawashiro, M Kawana… - Journal of the American …, 2011 - jacc.org
… Complete M-mode, 2-dimensional, and Doppler studies were performed with the patient in
the left lateral decubitus or supine position, using standard parasternal, apical, and subcostal …