… This block results in an accumulation of autophagosomes in the cytoplasm (Mauthe et al,
2018), which can contribute to an enhanced autophagosome-mediated signalling output (…

Macroautophagy (hereafter referred to as autophagy) is an evolutionarily conserved intracellular
catabolic transport route that generally allows the lysosomal degradation of cytoplasmic …

Macroautophagy/autophagy is a conserved transport pathway where targeted structures are
sequestered by phagophores, which mature into autophagosomes, and then delivered into …

… For freeze-fracture experiments, 1 mg of liposomes was incubated with 5 μM protein in
liposome buffer containing 0.3 M sucrose for 15 min at 37 C. Small aliquots (1 to 2 μl) of vesicle …

Coronavirus (CoV) nucleocapsid (N) proteins are key for incorporating genomic RNA into
progeny viral particles. In infected cells, N proteins are present at the replication-transcription …

The PI(3)K–PKB–FOXO signalling network provides a major intracellular hub for the regulation
of cell proliferation, survival and stress resistance. Here we report an unexpected role for …

The WDR45 gene is localized on the X-chromosome and variants in this gene are linked to
six different neurodegenerative disorders, ie, ß-propeller protein associated …

The integral membrane protein ATG9A plays a key role in autophagy. It displays a broad
intracellular distribution and is present in numerous compartments, including the plasma …

Canonical autophagy is positively regulated by the Beclin 1/phosphatidylinositol 3-kinase
class III (PtdIns3KC3) complex that generates an essential phospholipid, phosphatidylinositol 3…

Autophagy is initiated by multimembrane vesicle (autophagosome) formation upon
mammalian target of rapamycin inhibition and phosphatidylinositol 3-phosphate [PtdIns(3)P] …