User profiles for M. Mauthe
Mario MautheDepartment Biomedical Sciences of Cells & Systems, University of Groningen, UMCG Verified email at umcg.nl Cited by 17094 |
Hydroxychloroquine in rheumatic autoimmune disorders and beyond
EL Nirk, F Reggiori, M Mauthe - EMBO molecular medicine, 2020 - embopress.org
… This block results in an accumulation of autophagosomes in the cytoplasm (Mauthe et al,
2018), which can contribute to an enhanced autophagosome-mediated signalling output (…
2018), which can contribute to an enhanced autophagosome-mediated signalling output (…
Hidden behind autophagy: the unconventional roles of ATG proteins
J Bestebroer, P V'kovski, M Mauthe, F Reggiori - Traffic, 2013 - Wiley Online Library
Macroautophagy (hereafter referred to as autophagy) is an evolutionarily conserved intracellular
catabolic transport route that generally allows the lysosomal degradation of cytoplasmic …
catabolic transport route that generally allows the lysosomal degradation of cytoplasmic …
Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion
M Mauthe, I Orhon, C Rocchi, X Zhou, M Luhr… - Autophagy, 2018 - Taylor & Francis
Macroautophagy/autophagy is a conserved transport pathway where targeted structures are
sequestered by phagophores, which mature into autophagosomes, and then delivered into …
sequestered by phagophores, which mature into autophagosomes, and then delivered into …
Regulation of endoplasmic reticulum turnover by selective autophagy
…, L Liebmann, A Stolz, S Nietzsche, N Koch, M Mauthe… - Nature, 2015 - nature.com
… For freeze-fracture experiments, 1 mg of liposomes was incubated with 5 μM protein in
liposome buffer containing 0.3 M sucrose for 15 min at 37 C. Small aliquots (1 to 2 μl) of vesicle …
liposome buffer containing 0.3 M sucrose for 15 min at 37 C. Small aliquots (1 to 2 μl) of vesicle …
Nucleocapsid protein recruitment to replication-transcription complexes plays a crucial role in coronaviral life cycle
Coronavirus (CoV) nucleocapsid (N) proteins are key for incorporating genomic RNA into
progeny viral particles. In infected cells, N proteins are present at the replication-transcription …
progeny viral particles. In infected cells, N proteins are present at the replication-transcription …
Modulation of glutamine metabolism by the PI (3) K–PKB–FOXO network regulates autophagy
…, R Van Boxtel, M Putker, IJ Van Zutphen, M Mauthe… - Nature cell …, 2012 - nature.com
The PI(3)K–PKB–FOXO signalling network provides a major intracellular hub for the regulation
of cell proliferation, survival and stress resistance. Here we report an unexpected role for …
of cell proliferation, survival and stress resistance. Here we report an unexpected role for …
WDR45, one gene associated with multiple neurodevelopmental disorders
The WDR45 gene is localized on the X-chromosome and variants in this gene are linked to
six different neurodegenerative disorders, ie, ß-propeller protein associated …
six different neurodegenerative disorders, ie, ß-propeller protein associated …
[HTML][HTML] ATG9A protects the plasma membrane from programmed and incidental permeabilization
The integral membrane protein ATG9A plays a key role in autophagy. It displays a broad
intracellular distribution and is present in numerous compartments, including the plasma …
intracellular distribution and is present in numerous compartments, including the plasma …
Resveratrol-mediated autophagy requires WIPI-1-regulated LC3 lipidation in the absence of induced phagophore formation
M Mauthe, A Jacob, S Freiberger, K Hentschel… - Autophagy, 2011 - Taylor & Francis
Canonical autophagy is positively regulated by the Beclin 1/phosphatidylinositol 3-kinase
class III (PtdIns3KC3) complex that generates an essential phospholipid, phosphatidylinositol 3…
class III (PtdIns3KC3) complex that generates an essential phospholipid, phosphatidylinositol 3…
Ca2+/calmodulin-dependent kinase (CaMK) signaling via CaMKI and AMP-activated protein kinase contributes to the regulation of WIPI-1 at the onset of autophagy
Autophagy is initiated by multimembrane vesicle (autophagosome) formation upon
mammalian target of rapamycin inhibition and phosphatidylinositol 3-phosphate [PtdIns(3)P] …
mammalian target of rapamycin inhibition and phosphatidylinositol 3-phosphate [PtdIns(3)P] …