Sigma 1 receptor (σ 1 receptor) is a unique ligand-regulated molecular chaperone located
mainly in the endoplasmic reticulum and the plasma membrane. σ 1 receptor is activated …

Glutamate is probably the most important excitatory neurotransmitter in the brain. The glutamate
N-methyl-D-aspartate receptor (NMDAR) is a calcium-gated channel that coordinates …

Rupatadine is a new agent for the management of diseases with allergic inflammatory
conditions, such as seasonal and perennial rhinitis. The pharmacological profile of rupatadine …

Here we report that in skeletal muscle cells the contribution to insulin resistance and
inflammation of two common dietary long-chain fatty acids depends on the channeling of these …

Background: It has been reported that walnuts reduce serum cholesterol levels in normal
young men. Objective: To assess the acceptability of walnuts and their effects on serum lipid …

… Parallel MM calculations 13 further indicated conformer m to be 2.1 kcal/mol higher in energy
than M (Figure 3). Contrarily, no difference in energy was found for the two corresponding …

BACKGROUND AND PURPOSE The sigma‐1 (σ 1 ) receptor is a ligand‐regulated molecular
chaperone that has been involved in pain, but there is limited understanding of the actions …

The mechanisms responsible for increased expression of TNF-α in skeletal muscle cells in
diabetic states are not well understood. We examined the effects of the saturated acid …

… with [ 3 H]WEB-2086 (20 nM) for binding to platelet membranes was evaluated by adding
the antagonists at a minimum of eight appropriate concentrations between 10 −11 and 10 −5 M…

The synthesis and pharmacological activity of a series of bicyclic pyrazolo[1,5-a]pyrimidines
as potent and selective cyclooxygenase-2 (COX-2) inhibitors are described. The new …