Solubility, lipophilicity and membrane permeability of some fluoroquinolone antimicrobials

SV Blokhina, AV Sharapova, MV Ol'khovich… - European Journal of …, 2016 - Elsevier
… For the preparation of the buffer solution pH 2.0 (I = 0.10 mol/l) 6.57 g of KCl was dissolved
in water, 119.0 mL of 0.1 M hydrochloric acid was added and the volume of the solution was …

Synthesis and antifungal activity of new hybrids thiazolo [4, 5-d] pyrimidines with (1H-1, 2, 4) triazole

SV Blokhina, AV Sharapova, MV Ol'khovich… - Bioorganic & Medicinal …, 2021 - Elsevier
… The combination of several pharmacophore groups in the hybrid molecules has led to a
considerable increase in the molecular weight of the substances up to over 500 g∙mol −1 , which …

The pore-lipid interface: role of amino-acid determinants of lipophilic access by ivabradine to the hERG1 pore domain

…, M Kudaibergenova, J Lees-Miller, M Ol'khovich… - Molecular …, 2019 - ASPET
Abnormal cardiac electrical activity is a common side effect caused by unintended block of
the promiscuous drug target human ether-à-go-go-related gene (hERG1), the pore-forming …

Inclusion complex of antiasthmatic compound with 2-hydroxypropyl-β-cyclodextrin: preparation and physicochemical properties

MV Ol'khovich, AV Sharapova, GL Perlovich… - Journal of Molecular …, 2017 - Elsevier
This work aims at obtaining 2-hydroxypropyl-β-cyclodextrin inclusion complex with an original
antiasthmatic compound in buffer solution and solid state with higher solubility and, hence…

Sublimation thermodynamics of four fluoroquinolone antimicrobial compounds

S Blokhina, A Sharapova, M Ol'khovich… - The Journal of Chemical …, 2017 - Elsevier
… However, the levofloxacin sublimation enthalpy value (152.2 kJ/mol) obtained in this work
is only 7.7 kJ/mol lower than that of ciprofloxacin and higher than those of compounds II and III…

A thermodynamic study of sublimation, dissolution and distribution processes of anti-inflammatory drug Clonixin

S Blokhina, A Sharapova, M Ol'khovich… - The Journal of Chemical …, 2019 - Elsevier
… obtained in our experiments was Δ cr g H m ∘ = 90.5 ± 0.3 kJ·mol −1 . This is in good
agreement with the value recommended by IUPAC Δ cr g H m ∘ = 89.7 ± 0.5 kJ mol −1 ) [23]. …

[HTML][HTML] Experimental Examination of Solubility and Lipophilicity as Pharmaceutically Relevant Points of Novel Bioactive Hybrid Compounds

A Sharapova, M Ol'khovich, S Blokhina, GL Perlovich - Molecules, 2022 - mdpi.com
The important physicochemical properties of three novel bioactive hybrid compounds with
different groups (-CH 3 , -F and -Cl) were studied, including kinetic and thermodynamic …

Experimental solubility of clotrimazole and some thermodynamic aspects of dissolution in different solvents

S Blokhina, A Sharapova, M Ol'khovich, G Perlovich - Thermochimica acta, 2019 - Elsevier
Equilibrium solubility of clotrimazole, an important antimycotic drug, was measured between
(293.15–313.15) K in four pharmaceutically relevant solvents including buffer pH 2.0, buffer …

Experimental investigation of fluconazole: Equilibrium solubility and sublimation

S Blokhina, M Ol'khovich, A Sharapova… - The Journal of Chemical …, 2020 - Elsevier
m o θ θ + Δ cr g H m o θ 1 θ - 1 T + Δ cr g C p , m o θ θ T - 1 + ln T θ where Δ cr g H m o θ is
the standard molar sublimation enthalpy, Δ cr g G m o … , and Δ cr g C p , m o θ is the difference …

Vapor pressure and sublimation thermodynamics of aminobenzoic acid, nicotinic acid, and related amido-derivatives

…, AM Ryzhakov, AV Sharapova, MV Ol'khovich… - Journal of Thermal …, 2016 - Springer
The inert gas transpiration technique was used for measuring the vapor pressures of the
following biologically active compounds: 4-aminobenzoic acid, nicotinic acid, 4-…