Solubility, lipophilicity and membrane permeability of some fluoroquinolone antimicrobials
SV Blokhina, AV Sharapova, MV Ol'khovich… - European Journal of …, 2016 - Elsevier
… For the preparation of the buffer solution pH 2.0 (I = 0.10 mol/l) 6.57 g of KCl was dissolved
in water, 119.0 mL of 0.1 M hydrochloric acid was added and the volume of the solution was …
in water, 119.0 mL of 0.1 M hydrochloric acid was added and the volume of the solution was …
Synthesis and antifungal activity of new hybrids thiazolo [4, 5-d] pyrimidines with (1H-1, 2, 4) triazole
SV Blokhina, AV Sharapova, MV Ol'khovich… - Bioorganic & Medicinal …, 2021 - Elsevier
… The combination of several pharmacophore groups in the hybrid molecules has led to a
considerable increase in the molecular weight of the substances up to over 500 g∙mol −1 , which …
considerable increase in the molecular weight of the substances up to over 500 g∙mol −1 , which …
The pore-lipid interface: role of amino-acid determinants of lipophilic access by ivabradine to the hERG1 pore domain
…, M Kudaibergenova, J Lees-Miller, M Ol'khovich… - Molecular …, 2019 - ASPET
Abnormal cardiac electrical activity is a common side effect caused by unintended block of
the promiscuous drug target human ether-à-go-go-related gene (hERG1), the pore-forming …
the promiscuous drug target human ether-à-go-go-related gene (hERG1), the pore-forming …
Inclusion complex of antiasthmatic compound with 2-hydroxypropyl-β-cyclodextrin: preparation and physicochemical properties
MV Ol'khovich, AV Sharapova, GL Perlovich… - Journal of Molecular …, 2017 - Elsevier
This work aims at obtaining 2-hydroxypropyl-β-cyclodextrin inclusion complex with an original
antiasthmatic compound in buffer solution and solid state with higher solubility and, hence…
antiasthmatic compound in buffer solution and solid state with higher solubility and, hence…
Sublimation thermodynamics of four fluoroquinolone antimicrobial compounds
S Blokhina, A Sharapova, M Ol'khovich… - The Journal of Chemical …, 2017 - Elsevier
… However, the levofloxacin sublimation enthalpy value (152.2 kJ/mol) obtained in this work
is only 7.7 kJ/mol lower than that of ciprofloxacin and higher than those of compounds II and III…
is only 7.7 kJ/mol lower than that of ciprofloxacin and higher than those of compounds II and III…
A thermodynamic study of sublimation, dissolution and distribution processes of anti-inflammatory drug Clonixin
S Blokhina, A Sharapova, M Ol'khovich… - The Journal of Chemical …, 2019 - Elsevier
… obtained in our experiments was Δ cr g H m ∘ = 90.5 ± 0.3 kJ·mol −1 . This is in good
agreement with the value recommended by IUPAC Δ cr g H m ∘ = 89.7 ± 0.5 kJ mol −1 ) [23]. …
agreement with the value recommended by IUPAC Δ cr g H m ∘ = 89.7 ± 0.5 kJ mol −1 ) [23]. …
[HTML][HTML] Experimental Examination of Solubility and Lipophilicity as Pharmaceutically Relevant Points of Novel Bioactive Hybrid Compounds
A Sharapova, M Ol'khovich, S Blokhina, GL Perlovich - Molecules, 2022 - mdpi.com
The important physicochemical properties of three novel bioactive hybrid compounds with
different groups (-CH 3 , -F and -Cl) were studied, including kinetic and thermodynamic …
different groups (-CH 3 , -F and -Cl) were studied, including kinetic and thermodynamic …
Experimental solubility of clotrimazole and some thermodynamic aspects of dissolution in different solvents
S Blokhina, A Sharapova, M Ol'khovich, G Perlovich - Thermochimica acta, 2019 - Elsevier
Equilibrium solubility of clotrimazole, an important antimycotic drug, was measured between
(293.15–313.15) K in four pharmaceutically relevant solvents including buffer pH 2.0, buffer …
(293.15–313.15) K in four pharmaceutically relevant solvents including buffer pH 2.0, buffer …
Experimental investigation of fluconazole: Equilibrium solubility and sublimation
S Blokhina, M Ol'khovich, A Sharapova… - The Journal of Chemical …, 2020 - Elsevier
… m o θ θ + Δ cr g H m o θ 1 θ - 1 T + Δ cr g C p , m o θ θ T - 1 + ln T θ where Δ cr g H m o θ is
the standard molar sublimation enthalpy, Δ cr g G m o … , and Δ cr g C p , m o θ is the difference …
the standard molar sublimation enthalpy, Δ cr g G m o … , and Δ cr g C p , m o θ is the difference …
Vapor pressure and sublimation thermodynamics of aminobenzoic acid, nicotinic acid, and related amido-derivatives
…, AM Ryzhakov, AV Sharapova, MV Ol'khovich… - Journal of Thermal …, 2016 - Springer
The inert gas transpiration technique was used for measuring the vapor pressures of the
following biologically active compounds: 4-aminobenzoic acid, nicotinic acid, 4-…
following biologically active compounds: 4-aminobenzoic acid, nicotinic acid, 4-…