Smooth muscle cell plasticity: fact or fiction?
…, J Thyberg, DA Towler, MC Weiser-Evans… - Circulation …, 2013 - Am Heart Assoc
… Indeed, the results shown in Figure 2 herein, based on unpublished studies from the
laboratories of Drs Weiser-Evans and Miano, clearly show that SM MHC+ SMCs do, in fact, enter …
laboratories of Drs Weiser-Evans and Miano, clearly show that SM MHC+ SMCs do, in fact, enter …
The adventitia in arterial development, remodeling, and hypertension
MW Majesky, MCM Weiser-Evans - Biochemical Pharmacology, 2022 - Elsevier
The adventitia receives input signals from the vessel wall, the immune system, perivascular
nerves and from surrounding tissues to generate effector responses that regulate structural …
nerves and from surrounding tissues to generate effector responses that regulate structural …
Heterogeneous subpopulations of adventitial progenitor cells regulate vascular homeostasis and pathological vascular remodelling
…, KS Moulton, MCM Weiser-Evans - Cardiovascular …, 2022 - academic.oup.com
Cardiovascular diseases are characterized by chronic vascular dysfunction and provoke
pathological remodelling events, such as neointima formation, atherosclerotic lesion …
pathological remodelling events, such as neointima formation, atherosclerotic lesion …
Differentiated smooth muscle cells generate a subpopulation of resident vascular progenitor cells in the adventitia regulated by Klf4
…, RA Nemenoff, MCM Weiser-Evans - Circulation …, 2017 - Am Heart Assoc
… Unfortunately, because of premature death of SM22α-CreKI-YFP Klf4 SM-knockout mice
by 4 weeks of age 50 (MCM Weiser-Evans et al, unpublished data, 2014), we were unable to …
by 4 weeks of age 50 (MCM Weiser-Evans et al, unpublished data, 2014), we were unable to …
Selective class I histone deacetylase inhibition suppresses hypoxia-induced cardiopulmonary remodeling through an antiproliferative mechanism
…, DD Lemon, N Birdsey, MCM Weiser-Evans… - Circulation …, 2012 - Am Heart Assoc
Rationale: Histone deacetylase (HDAC) inhibitors are efficacious in models of hypertension-induced
left ventricular heart failure. The consequences of HDAC inhibition in the context of …
left ventricular heart failure. The consequences of HDAC inhibition in the context of …
The tumor microenvironment regulates sensitivity of murine lung tumors to PD-1/PD-L1 antibody blockade
…, TR Sippel, LE Heasley, MC Weiser-Evans… - Cancer immunology …, 2017 - AACR
Immune checkpoint inhibitors targeting the interaction between programmed cell death-1 (PD-1)
and its ligand PD-L1 induce tumor regression in a subset of non–small cell lung cancer …
and its ligand PD-L1 induce tumor regression in a subset of non–small cell lung cancer …
SDF-1α induction in mature smooth muscle cells by inactivation of PTEN is a critical mediator of exacerbated injury-induced neointima formation
…, S Offermanns, MCM Weiser-Evans - … , and vascular biology, 2011 - Am Heart Assoc
Objective— PTEN inactivation selectively in smooth muscle cells (SMC) initiates multiple
downstream events driving neointima formation, including SMC cytokine/chemokine production…
downstream events driving neointima formation, including SMC cytokine/chemokine production…
Complement Activation via a C3a Receptor Pathway Alters CD4+ T Lymphocytes and Mediates Lung Cancer Progression
…, AJ Neuwelt, SP Malkoski, MC Weiser-Evans… - Cancer research, 2018 - AACR
The complement cascade is a part of the innate immune system that acts primarily to remove
pathogens and injured cells. However, complement activation is also peculiarly associated …
pathogens and injured cells. However, complement activation is also peculiarly associated …
Expression profiling of macrophages reveals multiple populations with distinct biological roles in an immunocompetent orthotopic model of lung cancer
…, H Li, TR Sippel, M Weiser-Evans… - The Journal of …, 2016 - journals.aai.org
Macrophages represent an important component of the tumor microenvironment and play a
complex role in cancer progression. These cells are characterized by a high degree of …
complex role in cancer progression. These cells are characterized by a high degree of …
Targeted deletion of PTEN in smooth muscle cells results in vascular remodeling and recruitment of progenitor cells through induction of stromal cell–derived factor-1α
…, PJ Garl, J Cooper, MCM Weiser-Evans - Circulation …, 2008 - Am Heart Assoc
We previously showed that changes in vascular smooth muscle cell (SMC) PTEN/Akt signaling
following vascular injury are associated with increased SMC proliferation and neointima …
following vascular injury are associated with increased SMC proliferation and neointima …