User profiles for Maarten T. Huisman
Maarten HuismanUCB Verified email at ucb.com Cited by 2510 |
Significance of P-glycoprotein for the pharmacology and clinical use of HIV protease inhibitors
MT Huisman, JW Smit, AH Schinkel - Aids, 2000 - journals.lww.com
The inclusion of HIV protease inhibitor (PI) drugs in so-calledhighly active antiretroviral
therapy'(HAART) has substantially improved the clinical perspectives for HIV-infected individuals, …
therapy'(HAART) has substantially improved the clinical perspectives for HIV-infected individuals, …
[HTML][HTML] Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure
JW Smit, MT Huisman, O van Tellingen… - The Journal of …, 1999 - Am Soc Clin Investig
It was recently shown that naturally occurring Mdr1a mutant fetuses of the CF-1 outbred mouse
stock have no placental Mdr1a P-glycoprotein (P-gp) and that this absence is associated …
stock have no placental Mdr1a P-glycoprotein (P-gp) and that this absence is associated …
MRP2 (ABCC2) transports taxanes and confers paclitaxel resistance and both processes are stimulated by probenecid
MT Huisman, AA Chhatta… - … journal of cancer, 2005 - Wiley Online Library
ATP binding cassette (ABC) multidrug transporters such as P‐glycoprotein (P‐gp, ABCB1)
and BCRP (ABCG2) confer resistance against anticancer drugs and can limit their oral …
and BCRP (ABCG2) confer resistance against anticancer drugs and can limit their oral …
Multidrug resistance protein 2 (MRP2) transports HIV protease inhibitors, and transport can be enhanced by other drugs
MT Huisman, JW Smit, KML Crommentuyn, N Zelcer… - Aids, 2002 - journals.lww.com
Background: Various drug transporters of the ATP-binding cassette (ABC) family restrict the
oral bioavailability and cellular, brain, testis, cerebrospinal fluid and fetal penetration of …
oral bioavailability and cellular, brain, testis, cerebrospinal fluid and fetal penetration of …
[HTML][HTML] Evidence for two interacting ligand binding sites in human multidrug resistance protein 2 (ATP binding cassette C2)
Multidrug resistance protein 2 (MRP2) belongs to the ATP binding cassette family of
transporters. Its substrates include organic anions and anticancer drugs. We have used transport …
transporters. Its substrates include organic anions and anticancer drugs. We have used transport …
P-glycoprotein limits oral availability, brain, and fetal penetration of saquinavir even with high doses of ritonavir
MT Huisman, JW Smit, HR Wiltshire… - Molecular …, 2001 - ASPET
The low oral bioavailability of the HIV protease inhibitor (HPI) saquinavir is dramatically
increased by coadministration of the HPI ritonavir. Because saquinavir and ritonavir are …
increased by coadministration of the HPI ritonavir. Because saquinavir and ritonavir are …
Low systemic exposure of oral docetaxel in mice resulting from extensive first-pass metabolism is boosted by ritonavir
HA Bardelmeijer, M Ouwehand, T Buckle, MT Huisman… - Cancer research, 2002 - AACR
P-glycoprotein seems to be the most important factor limiting the oral absorption of paclitaxel.
We have now explored the mechanisms responsible for the low oral bioavailability of …
We have now explored the mechanisms responsible for the low oral bioavailability of …
Predicting carrier-mediated hepatic disposition of rosuvastatin in man by scaling from individual transfected cell-lines in vitro using absolute transporter protein …
…, ML Vlaming, KC Verhoeckx, MT Huisman… - European Journal of …, 2014 - Elsevier
In contrast to primary hepatocytes, estimating carrier-mediated hepatic disposition by using
a panel of single transfected cell-lines provides direct information on the contribution of the …
a panel of single transfected cell-lines provides direct information on the contribution of the …
A DGGE system for comprehensive mutation screening of BRCA1 and BRCA2: application in a Dutch cancer clinic setting
…, IM Mulder, P Vlies, P Elfferich, MT Huisman… - Human …, 2006 - Wiley Online Library
Rapid and reliable identification of deleterious changes in the breast cancer genes BRCA1
and BRCA2 has become one of the major issues in most DNA services laboratories. To …
and BRCA2 has become one of the major issues in most DNA services laboratories. To …
Drug-drug interactions between rosuvastatin and oral antidiabetic drugs occurring at the level of OATP1B1
Organic anion–transporting polypeptide 1B1 (OATP1B1) is an important hepatic uptake
transporter, of which the polymorphic variant OATP1B1*15 (Asn130Asp and Val174Ala) has …
transporter, of which the polymorphic variant OATP1B1*15 (Asn130Asp and Val174Ala) has …