User profiles for Madhu Kumar Venkatesh

Madhukumar Venkatesh

Albert Einstein College of Medicine
Verified email at aecom.yu.edu
Cited by 3039

[PDF][PDF] Structure and inhibition of microbiome β-glucuronidases essential to the alleviation of cancer drug toxicity

…, JD Ingle, KA Biernat, SJ Pellock, MK Venkatesh… - Chemistry & biology, 2015 - cell.com
The selective inhibition of bacterial β-glucuronidases was recently shown to alleviate drug-induced
gastrointestinal toxicity in mice, including the damage caused by the widely used …

Alleviating cancer drug toxicity by inhibiting a bacterial enzyme

…, KT Lane, JE Scott, J Orans, JS Koo, M Venkatesh… - Science, 2010 - science.org
The dose-limiting side effect of the common colon cancer chemotherapeutic CPT-11 is severe
diarrhea caused by symbiotic bacterial β-glucuronidases that reactivate the drug in the gut…

[HTML][HTML] Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4

M Venkatesh, S Mukherjee, H Wang, H Li, K Sun… - Immunity, 2014 - cell.com
Intestinal microbial metabolites are conjectured to affect mucosal integrity through an
incompletely characterized mechanism. Here we showed that microbial-specific indoles regulated …

Molecular insights into microbial β-glucuronidase inhibition to abrogate CPT-11 toxicity

AB Roberts, BD Wallace, MK Venkatesh, S Mani… - Molecular …, 2013 - ASPET
Bacterial β-glucuronidases expressed by the symbiotic intestinal microbiota appear to play
important roles in drug-induced epithelial cell toxicity in the gastrointestinal (GI) tract. For the …

[HTML][HTML] Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice

H Wang, M Venkatesh, H Li, R Goetz… - The Journal of …, 2011 - Am Soc Clin Investig
The nuclear receptor pregnane X receptor (PXR) is activated by a range of xenochemicals,
including chemotherapeutic drugs, and has been suggested to play a role in the …

The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor

…, TM Willson, GV Kalpana, M Venkatesh… - Molecular …, 2008 - academic.oup.com
Antagonizing the action of the human nuclear xenobiotic receptor pregnane X receptor (PXR)
may have important clinical implications in preventing drug-drug interactions and …

Expanding the roles for pregnane X receptor in cancer: proliferation and drug resistance in ovarian cancer

D Gupta, M Venkatesh, H Wang, S Kim, M Sinz… - Clinical Cancer …, 2008 - AACR
Purpose: We examined the presence of the pregnane X receptor (PXR) and its effects on
ovarian cancer cells after activation by its cognate ligand. Experimental Design: SKOV-3 and …

[HTML][HTML] Alleviation of gut inflammation by Cdx2/Pxr pathway in a mouse model of chemical colitis

W Dou, S Mukherjee, H Li, M Venkatesh, H Wang… - PloS one, 2012 - journals.plos.org
Pregnane X Receptor (PXR), a master regulator of drug metabolism and inflammation, is
abundantly expressed in the gastrointestinal tract. Baicalein and its O-glucuronide baicalin are …

[HTML][HTML] Pregnane X receptor regulates pathogen-induced inflammation and host defense against an intracellular bacterial infection through toll-like receptor 4

…, JL Cervantes, BB Cicek, S Mukherjee, M Venkatesh… - Scientific reports, 2016 - nature.com
The nuclear pregnane X receptor (PXR) plays a central role in regulating xenobiotic metabolism.
We now report a novel role for PXR as a critical negative regulator of innate immunity …

In vivo and in vitro characterization of a first-in-class novel azole analog that targets pregnane X receptor activation

M Venkatesh, H Wang, J Cayer, M Leroux… - Molecular …, 2011 - ASPET
The pregnane X receptor (PXR) is a master regulator of xenobiotic clearance and is implicated
in deleterious drug interactions (eg, acetaminophen hepatotoxicity) and cancer drug …