Stroke and circulatory arrest cause interferences in blood flow to the brain that result in
considerable tissue damage. The primary method to reduce or prevent neurologic damage to …

Cytochrome c (Cytc) is essential in mitochondrial electron transport and intrinsic type II
apoptosis. Mammalian Cytc also scavenges reactive oxygen species (ROS) under healthy …

The mitochondrial oxidative phosphorylation (OxPhos) system plays a key role in energy
production, the generation of free radicals, and apoptosis. A lack of cellular energy, excessive …

Cytochrome c (Cytc) and cytochrome c oxidase (COX) catalyze the terminal reaction of the
mitochondrial electron transport chain (ETC), the reduction of oxygen to water. This …

A new mechanism on regulation of mitochondrial energy metabolism is proposed on the
basis of reversible control of respiration by the intramitochondrial ATP/ADP ratio and slip of …

Apoptotic cell death can occur by two different pathways. Type 1 is initiated by the activation
of death receptors (Fas, TNF-receptor-family) on the plasma membrane followed by …

Thirty years after Peter Mitchell was awarded the Nobel Prize for the chemiosmotic hypothesis,
which links the mitochondrial membrane potential generated by the proton pumps of the …

BACKGROUND & AIMS: Air pollution is a global challenge to public health. Epidemiological
studies have linked exposure to ambient particulate matter with aerodynamic diameters<2.5…

Life of higher organisms is essentially dependent on the efficient synthesis of ATP by oxidative
phosphorylation in mitochondria. An important and as yet unsolved question of energy …

Both interleukin 1 beta (IL-1β) and interleukin-6 (IL-6) are pro-inflammatory cytokines that
play a major role in inflammatory diseases as well as cancer. In this work we investigated the …