A neuropeptide Y Y5 antagonist selectively ameliorates body weight gain and associated parameters in diet-induced obese mice
…, O Okamoto, N Sato, M Jitsuoka… - Proceedings of the …, 2006 - National Acad Sciences
Neuropeptide Y (NPY) is thought to have a major role in the physiological control of energy
homeostasis. Among five NPY receptors described, the NPY Y5 receptor (Y5R) is a prime …
homeostasis. Among five NPY receptors described, the NPY Y5 receptor (Y5R) is a prime …
Characterization of Neuropeptide Y (NPY) Y5 Receptor-Mediated Obesity in Mice: Chronic Intracerebroventricular Infusion of d-Trp34NPY
…, M Okawa, J Suzuki, T Fukuroda, M Jitsuoka… - …, 2003 - academic.oup.com
To clarify the role of the neuropeptide Y (NPY) Y5 receptor subtype in energy homeostasis,
the effect of the intracerebroventricular infusion of a selective Y5 agonist, d-Trp 34 NPY, was …
the effect of the intracerebroventricular infusion of a selective Y5 agonist, d-Trp 34 NPY, was …
Sepantronium bromide (YM155) enhances response of human B-cell non-Hodgkin lymphoma to rituximab
…, N Kaneko, M Nakata, K Yamanaka, M Jitsuoka… - … of Pharmacology and …, 2012 - ASPET
In the treatment of B-cell non-Hodgkin lymphoma (B-NHL) rituximab improves long-term
survival in combination with conventional chemotherapy. However, because the majority of …
survival in combination with conventional chemotherapy. However, because the majority of …
(9S)-9-(2-Hydroxy-4,4-dimethyl-6-oxo-1-cyclohexen-1-yl)-3,3-dimethyl-2,3,4,9-tetrahydro-1H-xanthen-1-one, a Selective and Orally Active Neuropeptide Y Y5 …
N Sato, M Jitsuoka, T Shibata, T Hirohashi… - Journal of medicinal …, 2008 - ACS Publications
(9S)-9-(2-Hydroxy-4,4-dimethyl-6-oxo-1-cyclohexen-1-yl)-3,3-dimethyl-2,3,4,9-tetrahydro-1H-xanthen-1-one
((S)-1) was identified as a selective and orally active neuropeptide Y Y5 …
((S)-1) was identified as a selective and orally active neuropeptide Y Y5 …
A pair-feeding study reveals that a Y5 antagonist causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure
…, Z Oda, R Moriya, H Matsushita, M Jitsuoka… - Molecular …, 2007 - ASPET
Neuropeptide Y (NPY) is thought to have a significant role in the physiological control of
energy homeostasis. We recently reported that an NPY Y5 antagonist inhibits body weight gain …
energy homeostasis. We recently reported that an NPY Y5 antagonist inhibits body weight gain …
Inverse agonist histamine H3 receptor PET tracers labelled with carbon‐11 or fluorine‐18
TG Hamill, N Sato, M Jitsuoka, S Tokita, S Sanabria… - Synapse, 2009 - Wiley Online Library
Two histamine H3 receptor (H3R) inverse agonist PET tracers have been synthesized and
characterized in preclinical studies. Each tracer has high affinity for the histamine H3 receptor, …
characterized in preclinical studies. Each tracer has high affinity for the histamine H3 receptor, …
Total Synthesis of (+)-7-Deoxypancratistatin and (+)-7-Deoxy-trans-dihydronarciclasine
N Chida, M Jitsuoka, Y Yamamoto, M Ohtsuka… - …, 1996 - keio.elsevierpure.com
The chiral and stereoselective synthesis of antimitotic phenanthridone alkaloids,(+)-7-deoxypancratistatin
(1) and (+)-7-deoxy-trans-dihydronarciclasine (2) is described. Both natural …
(1) and (+)-7-deoxy-trans-dihydronarciclasine (2) is described. Both natural …
Discovery of tetrasubstituted imidazolines as potent and selective neuropeptide Y Y5 receptor antagonists: reduced human ether-a-go-go related gene potassium …
N Sato, M Ando, S Ishikawa, M Jitsuoka… - Journal of medicinal …, 2009 - ACS Publications
A series of novel imidazoline derivatives was synthesized and evaluated as neuropeptide Y
(NPY) Y5 receptor antagonists. Optimization of previously reported imidazoline leads, 1a …
(NPY) Y5 receptor antagonists. Optimization of previously reported imidazoline leads, 1a …
Discovery of substituted 2, 4, 4-triarylimidazoline derivatives as potent and selective neuropeptide Y Y5 receptor antagonists
N Sato, M Jitsuoka, S Ishikawa, K Nagai… - Bioorganic & medicinal …, 2009 - Elsevier
Novel imidazoline derivatives were discovered to be potent neuropeptide Y Y5 receptor
antagonists. High-throughput screening of Merck sample collections against the human Y5 …
antagonists. High-throughput screening of Merck sample collections against the human Y5 …
Synthesis and evaluation of a spiro-isobenzofuranone class of histamine H3 receptor inverse agonists
M Jitsuoka, D Tsukahara, S Ito, T Tanaka… - Bioorganic & medicinal …, 2008 - Elsevier
Spiro-isobenzofuranones 1a and 1b were discovered as potent, selective, and brain-penetrable
non-imidazole H 3 receptor inverse agonists. Our corporate sample collection was …
non-imidazole H 3 receptor inverse agonists. Our corporate sample collection was …