[PDF][PDF] The G protein-coupled taste receptor T1R1/T1R3 regulates mTORC1 and autophagy
EM Wauson, E Zaganjor, AY Lee, ML Guerra… - Molecular cell, 2012 - cell.com
Cells continually assess their energy and nutrient state to maintain growth and survival and
engage necessary homeostatic mechanisms. Cell-autonomous responses to the fed state …
engage necessary homeostatic mechanisms. Cell-autonomous responses to the fed state …
2-amino-N-{4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-phenyl} acetamide (OSU-03012), a celecoxib derivative, directly targets p21-activated kinase
p21-Activated kinases (PAKs) are regulators of cell motility and proliferation. PAK activity is
regulated in part by phosphoinositide-dependent kinase 1 (PDK1). We hypothesized that …
regulated in part by phosphoinositide-dependent kinase 1 (PDK1). We hypothesized that …
Off-target effects of MEK inhibitors
EM Wauson, ML Guerra, B Barylko, JP Albanesi… - Biochemistry, 2013 - ACS Publications
The mitogen-activated protein kinases (MAPKs) ERK1/2 regulate numerous cellular processes,
including gene transcription, proliferation, and differentiation. The only known substrates …
including gene transcription, proliferation, and differentiation. The only known substrates …
Differential abundance of CK1α provides selectivity for pharmacological CK1α activators to target WNT-dependent tumors
…, X Chen, KC Kirkbride, T Doundoulakis, ML Guerra… - Science …, 2017 - science.org
Constitutive WNT activity drives the growth of various human tumors, including nearly all
colorectal cancers (CRCs). Despite this prominence in cancer, no WNT inhibitor is currently …
colorectal cancers (CRCs). Despite this prominence in cancer, no WNT inhibitor is currently …
Cav1. 2 and Cav1. 3 are differentially coupled to glucagon-like peptide-1 potentiation of glucose-stimulated insulin secretion in the pancreatic β-cell line INS-1
SMP Jacobo, ML Guerra, GH Hockerman - Journal of Pharmacology and …, 2009 - ASPET
The incretin peptides, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like
peptide-1 (GLP-1), potentiate glucose-stimulated insulin secretion (GSIS) and β-cell …
peptide-1 (GLP-1), potentiate glucose-stimulated insulin secretion (GSIS) and β-cell …
The intracellular II-III loops of Cav1. 2 and Cav1. 3 uncouple L-type voltage-gated Ca2+ channels from glucagon-like peptide-1 potentiation of insulin secretion in INS …
SMP Jacobo, ML Guerra, RE Jarrard, JA Przybyla… - Journal of pharmacology …, 2009 - ASPET
L-type Ca 2+ channels play a key role in the integration of physiological signals regulating
insulin secretion that probably requires their localization to specific subdomains of the plasma …
insulin secretion that probably requires their localization to specific subdomains of the plasma …
Ca2+ influx through L-type Ca2+ channels and Ca2+-induced Ca2+ release regulate cAMP accumulation and Epac1-dependent ERK 1/2 activation in INS-1 cells
EPS Pratt, AE Salyer, ML Guerra… - Molecular and cellular …, 2016 - Elsevier
We previously reported that INS-1 cells expressing the intracellular II-III loop of the L-type
Ca 2+ channel Ca v 1.2 (Ca v 1.2/II-III cells) are deficient in Ca 2+ -induced Ca 2+ release (…
Ca 2+ channel Ca v 1.2 (Ca v 1.2/II-III cells) are deficient in Ca 2+ -induced Ca 2+ release (…
Potentiation of sulfonylurea action by an EPAC-selective cAMP analog in INS-1 cells: comparison of tolbutamide and gliclazide and a potential role for EPAC …
…, AE Salyer, EPS Pratt, IM Soderling, ML Guerra… - Molecular …, 2013 - ASPET
Tolbutamide and gliclazide block the K ATP channel K ir 6.2/Sur1, causing membrane
depolarization and stimulating insulin secretion in pancreatic beta cells. We examined the ability …
depolarization and stimulating insulin secretion in pancreatic beta cells. We examined the ability …
Differential regulation of ERK1/2 and mTORC1 through T1R1/T1R3 in MIN6 cells
EM Wauson, ML Guerra, J Dyachok… - Molecular …, 2015 - academic.oup.com
The MAPKs ERK1/2 respond to nutrients and other insulin secretagogues in pancreatic β-cells
and mediate nutrient-dependent insulin gene transcription. Nutrients also stimulate the …
and mediate nutrient-dependent insulin gene transcription. Nutrients also stimulate the …
NeuroD1 mediates nicotine-induced migration and invasion via regulation of the nicotinic acetylcholine receptor subunits in a subset of neural and neuroendocrine …
JK Osborne, ML Guerra, JX Gonzales… - Molecular biology of …, 2014 - Am Soc Cell Biol
Cigarette smoking is a major risk factor for acquisition of small cell lung cancer (SCLC). A
role has been demonstrated for the basic helix-loop-helix transcription factor NeuroD1 in the …
role has been demonstrated for the basic helix-loop-helix transcription factor NeuroD1 in the …