Mitotic catastrophe, as defined in 2012 by the International Nomenclature Committee on Cell
Death, is a bona fide intrinsic oncosuppressive mechanism that senses mitotic failure and …

Gliomas are the most common primary tumours affecting the adult central nervous system
and respond poorly to standard therapy. Myc is causally implicated in most human tumours …

Effector caspases‐3, ‐6 and ‐7 are responsible for producing the morphological features
associated with apoptosis, such as DNA fragmentation. The present study demonstrates that a …

A sensitive method was developed for determining the phenylalanine hydroxylase activity of
crude tissue preparations in the presence of optimum concentrations of the 6,7-dimethyl-5,6,…

Skeletal dysplasias are a clinically and genetically heterogeneous group of bone and
cartilage disorders. Whilst >450 skeletal dysplasias have been reported, 30% are genetically …

Photodynamic therapy (PDT) is an established treatment modality for cancer. ADPM06 is an
emerging non‐porphyrin PDT agent which has been specifically designed for therapeutic …

We have investigated the induction of cell death in cultured cells by the virulent SFV4 and
avirulent A7 strains of Semliki Forest virus (SFV). In BHK cells, death occurred by a typical …

We have demonstrated previously that certain members of a series of novel pyrrolo-1,5-benzoxazepine
(PBOX) compounds potently induce apoptosis in a variety of human …

Daratumumab (DARA) has improved the outcome of treatment of multiple myeloma (MM).
DARA acts via complement-dependent and -independent mechanisms. Resistance to DARA …

We have recently developed five novel pyrrolo-1,5-benzoxazepines as proapoptotic agents.
Their JNK-dependent induction of apoptosis in tumor cells suggested their potential as …