The addictive potential of opioids may be related to their differential ability to induce G protein
signaling and endocytosis. We compared the ability of 20 ligands (sampled from the main …

Some spiro [piperidine-4, 2 (1 H)-quinazolin]-4 (3 H)-ones 3 and spiro [piperidine-4, 5 (6 H)-[1,
2, 4] triazolo-[1, 5-c] quinazolines] 4 were synthesized and evaluated as ligands of the …

A series of 4-amino-2-methylquinoline and 4-aminoquinazoline derivatives, including the
reference NOP antagonist JTC-801, were synthesized by an alternative pathway and their in …

Fusion proteins between heptahelical receptors (GPCR) and G protein α-subunits show
enhanced signaling efficiency in transfected cells. This is believed to be the result of molecular …

We engineered single and multiple mutations of serines 203, 204, and 207 in the fifth
transmembrane domain of the β 2 -adrenergic receptor, a region known to interact with hydroxyl …

We compared the changes in binding energy generated by two mutations that shift in
divergent directions the constitutive activity of the human β 2 adrenergic receptor (β 2 AR). A …

A small series of serotonin 5-HT 4 receptor ligands has been designed from flexible 2-methoxyquinoline
compounds 7a,b by applying the conformational constraint approach. Ligands …

Some synthesized 1,2-dihydrospiro[isoquinoline-4(3H),4′-piperidin]-3-ones were evaluated
as ligands for nociceptin receptor (NOP receptor). Their affinity was established by binding …

Substituted 4‐heteroaryl‐2‐phenylquinolines were synthesized and tested on NK‐2 and NK‐3
receptors in order to get a better insight in the structure‐activity relationship. On the whole…

Chloroform carcinogenicity has often been associated with acute tissue damage and
consequent compensatory cell proliferation. However, available data do not fully support this …