User profiles for Mark Cushman

Mark Cushman

Purdue University
Verified email at purdue.edu
Cited by 19173

Structures of three classes of anticancer agents bound to the human topoisomerase I− DNA covalent complex

BL Staker, MD Feese, M Cushman… - Journal of medicinal …, 2005 - ACS Publications
Human topoisomerase I (top1) is the molecular target of a diverse set of anticancer
compounds, including the camptothecins, indolocarbazoles, and indenoisoquinolines. These …

Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization

M Cushman, D Nagarathnam, D Gopal… - Journal of medicinal …, 1991 - ACS Publications
This compound was found to cause mitotic arrest in L1210 murine leukemia cells, inhibit
tubulin polymerization, and competitively inhibit the binding of radiolabeled colchicine to tubulin…

Synthesis and evaluation of analogs of (Z)-1-(4-methoxyphenyl)-2-(3, 4, 5-trimethoxyphenyl) ethene as potential cytotoxic and antimitotic agents

M Cushman, D Nagarathnam, D Gopal… - Journal of medicinal …, 1992 - ACS Publications
A series of stilbenes has been prepared and tested for cytotoxicity in the five human cancer
cell lines A-549 non-small cell lung, MCF-7 breast, HT-29 colon, SKMEL-5 melanoma, and …

Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites

…, S Mo, Y Li, M Cushman - Journal of medicinal …, 2010 - ACS Publications
Five resveratrol sulfate metabolites were synthesized and assessed for activities known to
be mediated by resveratrol: inhibition of tumor necrosis factor (TNF) α induced NFκB activity, …

Synthesis, antitubulin and antimitotic activity, and cytotoxicity of analogs of 2-methoxyestradiol, an endogenous mammalian metabolite of estradiol that inhibits tubulin …

M Cushman, HM He… - Journal of medicinal …, 1995 - ACS Publications
In order to define the structural parameters associated with the antitubulin activity and
cytotoxicity of 2-methoxyestradiol, a mammalian metabolite of estradiol, an array of analogs was …

Synthesis of New Indeno[1,2-c]isoquinolines:  Cytotoxic Non-Camptothecin Topoisomerase I Inhibitors

M Cushman, M Jayaraman, JA Vroman… - Journal of medicinal …, 2000 - ACS Publications
In an attempt to design and synthesize potential anticancer agents acting by inhibition of
topoisomerase I (top1), a new series of indenoisoquinolines was prepared and tested for …

The indenoisoquinoline noncamptothecin topoisomerase I inhibitors: update and perspectives

Y Pommier, M Cushman - Molecular cancer therapeutics, 2009 - AACR
Because camptothecins are effective against previously resistant tumors and are the only
class of topoisomerase I (Top1) inhibitors approved for cancer treatment, we developed the …

Protein-linked DNA strand breaks induced by NSC 314622, a novel noncamptothecin topoisomerase I poison

G Kohlhagen, KD Paull, M Cushman, P Nagafuji… - Molecular …, 1998 - ASPET
NSC 314622 was found to have a cytotoxicity profile comparable to the topoisomerase I (top1)
inhibitors camptothecin (CPT) and saintopin in the National Cancer Institute In Vitro …

Synthesis of cytotoxic indenoisoquinoline topoisomerase I poisons

…, M Jayaraman, P Nagafuji, M Cushman - Journal of medicinal …, 1999 - ACS Publications
A number of indenoisoquinolines were prepared and evaluated for cytotoxicity in human
cancer cell cultures and for activity vs topoisomerase 1 (top1). The two most cytotoxic …

Synthesis and protein-tyrosine kinase inhibitory activity of polyhydroxylated stilbene analogs of piceatannol

…, RL Geahlen, M Cushman - Journal of medicinal …, 1993 - ACS Publications
At this juncture, benzyl groups were tried to protect the phenols. A series of diethyl
benzylphosphonat. es 7a-e were prepared with benzyl protecting groups (Scheme I) and reacted …