Cells induce the expression of DNA-repair enzymes, activate cell-cycle checkpoints and,
under some circumstances, undergo apoptosis in response to DNA-damaging agents. The …

The tumor suppressor protein, p53, is part of the cell's emergency team that is called upon
following cellular insult. How do cells sense DNA damage and other cellular stresses and …

US general Ulysses S. Grant once said:“The art of war is simple enough. Find out where
your enemy is. Get at him as soon as you can. Strike him as hard as you can.” The decision-…

To study the triggering mechanism (s) of the induction of apoptosis following exposure to uv
light, we used a genetic approach involving cell strains derived from patients with inherited …

The mechanisms by which the p53 response is triggered following exposure to DNA-damaging
agents have not yet been clearly elucidated. We and others have previously suggested …

The rate of transcription elongation plays an important role in the timing of expression of full-length
transcripts as well as in the regulation of alternative splicing. In this study, we coupled …

Pancreatic cancer is a deadly disease characterized by late diagnosis and resistance to
therapy. Much progress has been made in defining gene defects in pancreatic cancer, but a full …

Long non-coding RNAs (lncRNAs) represent an emerging layer of cancer biology,
contributing to tumor proliferation, invasion, and metastasis. Here, we describe a role for the …

It has been suggested that phosphorylation of the histone variant H2AX after ultraviolet light
(UV) irradiation is triggered by DNA double-strand breaks induced as replication forks …

Patients with glioma whose tumors carry a mutation in isocitrate dehydrogenase 1 (IDH1
R132H ) are younger at diagnosis and live longer. IDH1 mutations co-occur with other …