Attention-deficit hyperactivity disorder (ADHD) has been shown to be familial and heritable,
in previous studies. As with most psychiatric disorders, examination of pedigrees has not …

Volatile anaesthetics have historically been considered to act in a nonspecific manner on
the central nervous system 1 , 2 . More recent studies, however, have revealed that the …

γ-Aminobutyric acid type A receptors (GABA A -Rs) mediate the bulk of rapid inhibitory synaptic
transmission in the central nervous system. The β3 subunit is an essential component of …

Biliary bile salt composition of 677 vertebrate species (103 fish, 130 reptiles, 271 birds, 173
mammals) was determined. Bile salts were of three types: C 27 bile alcohols, C 27 bile acids, …

One approach to speed up drug discovery is to examine new uses for existing approved
drugs, so-called ‘drug repositioning’ or ‘drug repurposing’, which has become increasingly …

Both volatile and intravenous general anesthetics allosterically enhance γ-aminobutyric acid
(GABA)-evoked chloride currents at the GABA type A (GABA A ) receptor. Recent work has …

A series of 27 analogs of the general anesthetic propofol (2,6-diisopropylphenol) were
examined for general anesthetic activity in Xenopus laevis tadpoles and for the ability to produce …

In the past twenty years, 14 new antiepileptic drugs have been approved for use in the United
States and/or Europe. These drugs are eslicarbazepine acetate, felbamate, gabapentin, …

Background Immunoassays are widely used in clinical laboratories for measurement of
plasma/serum concentrations of steroid hormones such as cortisol and testosterone. …

The pregnane X receptor (PXR; NR1I2), a member of the nuclear receptor superfamily,
regulates the expression of drug-metabolic enzymes and transporters involved in the responses …