User profiles for Matthias U. Kassack

Matthias Kassack

Professor
Verified email at uni-duesseldorf.de
Cited by 7644

Comparison of the usefulness of the MTT, ATP, and calcein assays to predict the potency of cytotoxic agents in various human cancer cell lines

H Mueller, MU Kassack, M Wiese - SLAS Discovery, 2004 - Elsevier
Cell viability assays are important tools in oncological research and clinical practice to
assess the tumor cell sensitivity of individual patients. The purpose of this study was to …

Common variants in P2RY11 are associated with narcolepsy

…, H Kuipers, K Weiner, A Hamacher, MU Kassack… - Nature …, 2011 - nature.com
Growing evidence supports the hypothesis that narcolepsy with cataplexy is an autoimmune
disease. We here report genome-wide association analyses for narcolepsy with replication …

Histone deacetylase (HDAC) inhibitors with a novel connecting unit linker region reveal a selectivity profile for HDAC4 and HDAC5 with improved activity against …

…, K Kuna, H Gohlke, MU Kassack… - Journal of medicinal …, 2013 - ACS Publications
The synthesis and biological evaluation of new potent hydroxamate-based HDAC inhibitors
with a novel alkoxyamide connecting unit linker region are described. Biological evaluation …

Structure–Activity Studies on Suramin Analogues as Inhibitors of NAD+‐Dependent Histone Deacetylases (Sirtuins)

…, R Meier, D Hongwiset, MU Kassack… - ChemMedChem …, 2007 - Wiley Online Library
Suramin is a symmetric polyanionic naphthylurea originally used for the treatment of
trypanosomiasis and onchocerciasis. Suramin and diverse analogues exhibit a broad range of …

Hyperactivation of the insulin-like growth factor receptor I signaling pathway is an essential event for cisplatin resistance of ovarian cancer cells

…, I Napierski, A Hamacher, MU Kassack… - Cancer research, 2009 - AACR
Platinum plays a central role in the therapy of ovarian cancer, and the emergence of platinum
resistance is a major obstacle for clinical management of the disease. We treated A2780 …

Relevance of drug uptake and efflux for cisplatin sensitivity of tumor cells

…, MU Kassack, M Osmak, U Jaehde - Biochemical …, 2007 - Elsevier
Platinum sensitivity and platinum resistance may involve altered activity of transport proteins.
In order to assess the role of drug uptake and efflux in this phenomenon, we compared the …

[HTML][HTML] Extracellular NAD+ is an agonist of the human P2Y11 purinergic receptor in human granulocytes

…, F Benvenuto, C Usai, S Meis, MU Kassack… - Journal of Biological …, 2006 - ASBMB
Micromolar concentrations of extracellular β-NAD + (NAD e + ) activate human granulocytes
(superoxide and NO generation and chemotaxis) by triggering: (i) overproduction of cAMP, (…

Inhibition of neutrophil apoptosis by ATP is mediated by the P2Y11 receptor

…, HM Marriott, S Meis, MU Kassack… - The Journal of …, 2007 - journals.aai.org
Neutrophils undergo rapid constitutive apoptosis that is delayed by a range of pathogen-and
host-derived inflammatory mediators. We have investigated the ability of the nucleotide ATP…

Discovery of Potent and Selective Agonists for the Free Fatty Acid Receptor 1 (FFA1/GPR40), a Potential Target for the Treatment of Type II Diabetes

…, C Drewke, S Ullrich, MU Kassack… - Journal of medicinal …, 2008 - ACS Publications
A series of 4-phenethynyldihydrocinnamic acid agonists of the free fatty acid receptor 1 (FFA
1 ) has been discovered and explored. The preferred compound 20 (TUG-424, EC 50 = 32 …

Three diketopiperazine alkaloids with spirocyclic skeletons and one bisthiodiketopiperazine derivative from the mangrove-derived endophytic fungus Penicillium …

…, CY Wang, A Mándi, XM Li, XY Hu, MU Kassack… - Organic …, 2016 - ACS Publications
Four new diketopiperazines including spirobrocazines A–C (1–3) and brocazine G (4) were
characterized from the mangrove-derived Penicillium brocae MA-231. Compounds 1 and 2 …