A recent phase 1 trial of the fatty acid amide hydrolase (FAAH) inhibitor BIA 10-2474 led to
the death of one volunteer and produced mild-to-severe neurological symptoms in four others…

In 1964, the psychoactive ingredient of Cannabis sativa, Δ 9 -tetrahydrocannabinol (THC),
was isolated. Nearly 30 years later the endogenous counterparts of THC, collectively termed …

The endocannabinoid anandamide (AEA) is shown to induce apoptotic bodies formation
and DNA fragmentation, hallmarks of programmed cell death, in human neuroblastoma …

Of the endocannabinoids (eCBs), anandamide (AEA) and 2-arachidonoylglycerol (2-AG)
have received the most study. A functional interaction between these molecules has never …

Inflammation is an immune response that works as a contained fire that is pre-emptively
sparked as a defensive process during infections or upon any kind of tissue insult, and that is …

The endogenous ligand of CB 1 cannabinoid receptors, anandamide, is also a full agonist
at vanilloid VR1 receptors for capsaicin and resiniferatoxin, thereby causing an increase in …

Cannabinoid receptors and their endogenous ligands have been recently identified in the
brain as potent inhibitors of neurotransmitter release. Here we show that, in a rat model of …

Resolution of inflammation is a finely regulated process mediated by specialized proresolving
lipid mediators (SPMs), including docosahexaenoic acid (DHA)–derived resolvins and …

Among the many signalling lipids, endocannabinoids are increasingly recognized for their
important roles in neuronal and glial development. Recent experimental evidence suggests …

Mammalian reproduction is a complicated process designed to diversify and strengthen the
genetic complement of the offspring and to safeguard regulatory systems at various steps for …