Molecular immune mechanism of C‐phycocyanin from Spirulina platensis induces apoptosis in HeLa cells in vitro

B Li, MH Gao, XC Zhang… - Biotechnology and applied …, 2006 - Wiley Online Library
C‐phycocyanin (C‐PC), a water‐soluble protein pigment, isolated from Spirulina platensis,
is of great importance because of its various medical and pharmacological properties. In the …

Intracoronary adenovirus encoding adenylyl cyclase VI increases left ventricular function in heart failure

NC Lai, DM Roth, MH Gao, T Tang, N Dalton, YY Lai… - Circulation, 2004 - Am Heart Assoc
Background— We tested the hypothesis that intracoronary delivery of an adenovirus encoding
adenylyl cyclase type VI (Ad.AC VI ) would be associated with increased left ventricular (…

Adenylylcyclase increases responsiveness to catecholamine stimulation in transgenic mice

MH Gao, NC Lai, DM Roth, J Zhou, J Zhu, T Anzai… - Circulation, 1999 - Am Heart Assoc
Background—The cellular content of cAMP generated by activation of adenylylcyclase (AC)
through the β-adrenergic receptor (βAR) is a key determinant of a cell’s response to …

The synergistic antitumor effects of all-trans retinoic acid and C-phycocyanin on the lung cancer A549 cells in vitro and in vivo

B Li, MH Gao, XM Chu, L Teng, CY Lv, P Yang… - European journal of …, 2015 - Elsevier
The anticancer effects and mechanism of all-trans retinoic acid (ATRA), C-phycocyanin (C-PC)
or ATRA+C-PC on the growth of A549 cells were studied in in vitro and in vivo …

Intracoronary gene transfer of adenylyl cyclase 6 in patients with heart failure: a randomized clinical trial

…, ML Lee, SM Narayan, DG Blanchard, MH Gao - JAMA …, 2016 - jamanetwork.com
Importance Gene transfer has rarely been tested in randomized clinical trials. Objective To
evaluate the safety and efficacy of intracoronary delivery of adenovirus 5 encoding adenylyl …

Cardiac-directed adenylyl cyclase expression improves heart function in murine cardiomyopathy

DM Roth, MH Gao, NC Lai, J Drumm, N Dalton… - Circulation, 1999 - Am Heart Assoc
Background—We tested the hypothesis that increased cardiac myocyte adenylyl cyclase (AC)
content increases cardiac function and response to catecholamines in cardiomyopathy. …

Adenylyl cyclase increases survival in cardiomyopathy

DM Roth, H Bayat, JD Drumm, MH Gao, JS Swaney… - Circulation, 2002 - Am Heart Assoc
Background— To test the hypothesis that increased cardiac adenylyl cyclase type VI (AC VI
) content, which results in increased cAMP generation, would increase survival in …

Adenylyl cyclase type 6 deletion decreases left ventricular function via impaired calcium handling

T Tang, MH Gao, NC Lai, AL Firth, T Takahashi, T Guo… - Circulation, 2008 - Am Heart Assoc
Background— Adenylyl cyclases (ACs) are a family of effector molecules for G-protein–coupled
receptors. The 2 ACs most abundantly expressed in cardiac myocytes are types 5 (AC5) …

Apoptotic mechanism of MCF-7 breast cells in vivo and in vitro induced by photodynamic therapy with C-phycocyanin

B Li, X Chu, M Gao, W Li - Acta Biochim Biophys Sin, 2010 - academic.oup.com
The aim of this study was to investigate the pro-apoptotic mechanism of C-phycocyanin (C-PC)-mediated
photodynamic therapy (PDT) in a murine tumor model and cultured MCF-7 cells…

Intracoronary delivery of adenovirus encoding adenylyl cyclase VI increases left ventricular function and cAMP-generating capacity

NC Lai, DM Roth, MH Gao, S Fine, BP Head, J Zhu… - Circulation, 2000 - Am Heart Assoc
Background—We tested the hypothesis that intracoronary injection of a recombinant
adenovirus encoding adenylyl cyclase type VI (AC VI ) would increase cardiac function in pigs. …