Germline mutation in serine/threonine kinase 11 (STK11, also called LKB1) results in Peutz–Jeghers
syndrome, characterized by intestinal hamartomas and increased incidence of …

Non-small cell lung cancers with activating mutations in the epidermal growth factor receptor
(EGFR) are highly responsive to EGFR tyrosine kinase inhibitors (TKIs), such as gefitinib …

Genome-wide copy number analyses of human cancers identified a frequent 5p13
amplification in several solid tumour types, including lung (56%), ovarian (38%), breast (32%), …

Transcription factor NF-κB is constitutively active in many human chronic inflammatory
diseases and cancers. Epoxyquinone A monomer (EqM), a synthetic derivative of the natural …

The novel concept of modifying and enhancing the properties of existing functional micelles
through self-complementary interactions has significant potential. In this study, a practical …

ErbB3 is a critical activator of phosphoinositide 3-kinase (PI3K) signaling in epidermal
growth factor receptor (EGFR; ErbB1), ErbB2 [human epidermal growth factor receptor 2 (HER2)], …

The EGFR T790M mutation has been identified in tumors from lung cancer patients that
eventually develop resistance to erlotinib. In this study, we generated a mouse model with …

Small cell lung carcinoma (SCLC) is a neuroendocrine subtype of lung cancer that affects
more than 200,000 people worldwide every year with a very high mortality rate. Here, we used …

Mutations in the BRAF and KRAS genes occur in ∼1% to 2% and 20% to 30% of non–small-cell
lung cancer patients, respectively, suggesting that the mitogen-activated protein kinase (…

Activation of the Rel/NF-κB signal transduction pathway has been associated with a variety
of animal and human malignancies. However, among the Rel/NF-κB family members, only c-…