User profiles for Michael S. Dahabieh
Michael DahabiehPost Doctoral Fellow, Van Andel Institute Verified email at vai.org Cited by 331 |
[PDF][PDF] Carbon source availability drives nutrient utilization in CD8+ T cells
How environmental nutrient availability impacts T cell metabolism and function remains
poorly understood. Here, we report that the presence of physiologic carbon sources (PCSs) in …
poorly understood. Here, we report that the presence of physiologic carbon sources (PCSs) in …
[PDF][PDF] Ketolysis drives CD8+ T cell effector function through effects on histone acetylation
Environmental nutrient availability influences T cell metabolism, impacting T cell function
and shaping immune outcomes. Here, we identified ketone bodies (KBs)—including β-…
and shaping immune outcomes. Here, we identified ketone bodies (KBs)—including β-…
Peroxisomes and cancer: The role of a metabolic specialist in a disease of aberrant metabolism
MS Dahabieh, E Di Pietro, M Jangal… - … et Biophysica Acta (BBA …, 2018 - Elsevier
Cancer is irrevocably linked to aberrant metabolic processes. While once considered a
vestigial organelle, we now know that peroxisomes play a central role in the metabolism of …
vestigial organelle, we now know that peroxisomes play a central role in the metabolism of …
[HTML][HTML] Peroxisome disruption alters lipid metabolism and potentiates antitumor response with MAPK-targeted therapy in melanoma
Melanomas reprogram their metabolism to rapidly adapt to therapy-induced stress conditions,
allowing them to persist and ultimately develop resistance. We report that a subpopulation …
allowing them to persist and ultimately develop resistance. We report that a subpopulation …
[HTML][HTML] Peroxisomes protect lymphoma cells from HDAC inhibitor-mediated apoptosis
MS Dahabieh, ZY Ha, E Di Pietro, JN Nichol… - Cell Death & …, 2017 - nature.com
Peroxisomes are a critical rheostat of reactive oxygen species (ROS), yet their role in drug
sensitivity and resistance remains unexplored. Gene expression analysis of clinical lymphoma …
sensitivity and resistance remains unexplored. Gene expression analysis of clinical lymphoma …
Prior metabolite extraction fully preserves RNAseq quality and enables integrative multi-'omics analysis of the liver metabolic response to viral infection
ZB Madaj, MS Dahabieh, V Kamalumpundi… - RNA biology, 2023 - Taylor & Francis
Here, we provide an in-depth analysis of the usefulness of single-sample metabolite/RNA
extraction for multi-‘omics readout. Using pulverized frozen livers of mice injected with …
extraction for multi-‘omics readout. Using pulverized frozen livers of mice injected with …
MNK1 signaling induces an ANGPTL4-mediated gene signature to drive melanoma progression
…, Y Zhan, D Plourde, JN Nichol, MS Dahabieh… - Oncogene, 2020 - nature.com
The BRAF V600E mutation occurs in more than 50% of cutaneous melanomas, and results
in the constitutive activation of the mitogen-activated protein kinases (MAPK) pathway. MAP …
in the constitutive activation of the mitogen-activated protein kinases (MAPK) pathway. MAP …
The novel arsenical darinaparsin is transported by cystine importing systems
N Garnier, GGJ Redstone, MS Dahabieh… - Molecular …, 2014 - ASPET
Darinaparsin (Dar; ZIO-101; S-dimethylarsino-glutathione) is a promising novel organic
arsenical currently undergoing clinical studies in various malignancies. Dar consists of …
arsenical currently undergoing clinical studies in various malignancies. Dar consists of …
[HTML][HTML] The role of eIF4E in response and acquired resistance to vemurafenib in melanoma
Y Zhan, MS Dahabieh, A Rajakumar… - Journal of Investigative …, 2015 - Elsevier
In eukaryotic cells, the rate-limiting component for cap-dependent mRNA translation is the
translation initiation factor eIF4E. eIF4E is overexpressed in a variety of human malignancies, …
translation initiation factor eIF4E. eIF4E is overexpressed in a variety of human malignancies, …
Silencing PEX26 as an unconventional mode to kill drug-resistant cancer cells and forestall drug resistance
MS Dahabieh, F Huang, C Goncalves… - Autophagy, 2022 - Taylor & Francis
Promoting the macroautophagy/autophagy-mediated degradation of specific proteins and
organelles can potentially be utilized to induce apoptosis in cancer cells or sensitize tumor …
organelles can potentially be utilized to induce apoptosis in cancer cells or sensitize tumor …