Neutrophils are frontline cells of the innate immune system. These effector leukocytes are
equipped with intriguing antimicrobial machinery and consequently display high cytotoxic …

Chemokines are an indispensable component of our immune system through the regulation
of directional migration and activation of leukocytes. CXCL8 is the most potent human …

Epidemiological and clinical reports indicate that SARS-CoV-2 virulence hinges upon the
triggering of an aberrant host immune response, more so than on direct virus-induced cellular …

Serum amyloid A (SAA) is, like C-reactive protein (CRP), an acute phase protein and can be
used as a diagnostic, prognostic or therapy follow-up marker for many diseases. Increases …

The inflammatory response is a highly co-ordinated process involving multiple factors acting
in a complex network as stimulators or inhibitors. Upon infection, the sequential release of …

Biological functions of proteins are influenced by posttranslational modifications such as on/off
switching by phosphorylation and modulation by glycosylation. Proteolytic processing …

The precise role of chemokines in neovascularization during inflammation or tumor growth
is not yet fully understood. We show here that the chemokines granulocyte chemotactic …

Interactions between chemokines and enzymes are vital in immunoregulation. Structural
protein citrullination by peptidylarginine deiminase (PAD) has been associated with …

The chemokine dose and the time period during which the chemotactic gradient is
established determine the number of leukocytes that infiltrate inflamed tissues. At suboptimal …

Levels of serum amyloid A (SAA), a major acute phase protein in humans, are increased up
to 1000-fold upon infection, trauma, cancer or other inflammatory events. However, the exact …