Prucalopride is a novel enterokinetic compound and is the first representative of the benzofuran
class. We set out to establish its pharmacological profile in various receptor binding and …

Information on the neuroanatomical expression of a given gene is critical to understanding
its function in the central nervous system. The integration of laser capture microdissection (…

The cloning of novel G protein-coupled receptors and the search for their natural ligands, a
process called reverse pharmacology, is an excellent opportunity to discover novel …

The anatomical localization of 5‐HT 4 receptor mRNA and 5‐HT 4 receptor protein was
examined in sections of post‐mortem human brain by in situ hybridization histochemistry and …

This study documents differences in ligand binding and signal transduction properties
between the human (h) 5-hydroxytryptamine (5-HT) 4a and h5-HT 4b receptor splice variants …

Several variants of the serotonin 5‐HT 4 receptor are known to be produced by alternative
splicing. To survey the existence and usage of exons in humans, we cloned the human 5‐HT …

The G protein coupling of human 5-hydroxytryptamine 5A (h5-ht 5A ) receptors was investigated
in stably transfected human embryonic kidney (HEK) 293 cells, using radioligand and …

The neurokinin 3 (NK3) receptor is predominantly expressed in the central nervous system (CNS).
Species differences in neurokinin 3 (NK3) receptor pharmacology have led to the …

In oncology, the “Warburg effect” describes the elevated production of energy by glycolysis
in cancer cells. The ubiquitous and hypoxia-induced 6-phosphofructo-2-kinase/fructose-2,6-…

The neurokinin 3 (NK3) receptor antagonists represent a novel class of pharmacological
agents, which are currently under evaluation for the treatment of psychiatric disorders. An …