For the past 30 years strategies for the preclinical discovery and development of potential
anticancer agents have been based largely upon the testing of agents in mice bearing …

2, 5-bis(5-Hydroxymethyl-2-thienyl)furan (NSC 652287), is a representative of a series of
thiophene derivatives that exhibit potent and selective antitumor activity against several tumor …

The quaternized ellipticine derivative, 9-methoxy-N 2 -methylellipticinium acetate (MMEA),
is representative of a group of ellipticinium compounds found preferentially cytotoxic to …

Both cells recently explanted and long-term lines derived from fetal tissues of the mouse,
Syrian hamster, and rat and adult tissue of the Chinese hamster were given either single, short (…

The ruthenium red-staining coat (RRSC) of a pair of neoplastic and nonneoplastic cell lines
derived from a common pool of mouse embryo cells was examined by electron microscopy. …

In previous studies on factors influencing clonal growth in vitro, a gas phase containing 1%
O 2 , compared with atmospheric O 2 (20%), enhanced plating efficiency (PE). To evaluate …

Targeting CD22 on human B-cells with a monoclonal antibody conjugated to a cytotoxic
RNAse causes potent and specific killing of the lymphoma cells in vitro. This translates to anti-…

The ability of interleukin 2 (IL 2), interleukin 3 (IL 3), and granulocyte/macrophage colony-stimulating
factor (GM-CSF) to induce the proliferation of cells from thymus, spleen, or bone …

ABBREVIATIONS: DiBAC4 (3), bis (1, 3-dibutylbarbitunic acid) tnimethine oxonol; FCCP,
carbonyl cyanide p-(trifluoromethoxy) phenylhydrazone;[K] 0, extracellular potassium …

Behavioral headache treatments have garnered solid empirical support in recent years, but
there is substantial opportunity to strengthen the next generation of studies with improved …