User profiles for Monica Soto-Velasquez

MONICA LUCIA SOTO VELASQUEZ

Profesor Universidad de Antioquia
Verified email at udea.edu.co
Cited by 848

Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties

TF Brust, D Alongkronrusmee, M Soto-Velasquez… - Science …, 2017 - science.org
Adenylyl cyclase 1 (AC1) belongs to a group of adenylyl cyclases (ACs) that are stimulated
by calcium in a calmodulin-dependent manner. Studies with AC1 knockout mice suggest that …

Optimization of a 1, 3, 4-oxadiazole series for inhibition of Ca2+/calmodulin-stimulated activity of adenylyl cyclases 1 and 8 for the treatment of chronic pain

J Kaur, M Soto-Velasquez, Z Ding… - European journal of …, 2019 - Elsevier
Adenylyl cyclases type 1 (AC1) and 8 (AC8) are group 1 transmembrane adenylyl cyclases (AC)
that are stimulated by Ca 2+ /calmodulin. Studies have shown that mice depleted of …

A novel CRISPR/Cas9-Based cellular model to explore adenylyl cyclase and cAMP signaling

M Soto-Velasquez, MP Hayes, A Alpsoy… - Molecular …, 2018 - ASPET
Functional characterization of adenylyl cyclase (AC) isoforms has proven challenging in
mammalian cells because of the endogenous expression of multiple AC isoforms and the high …

Identification of FDA-approved small molecules capable of disrupting the calmodulin–adenylyl cyclase 8 interaction through direct binding to calmodulin

MP Hayes, M Soto-Velasquez, CA Fowler… - ACS chemical …, 2018 - ACS Publications
Adenylyl cyclases (AC) catalyze the formation of cyclic AMP (cAMP) from ATP and are
involved in a number of disease states, making them attractive potential drug targets. AC8, in …

[HTML][HTML] Identification of Novel Adenylyl Cyclase 5 (AC5) Signaling Networks in D1 and D2 Medium Spiny Neurons using Bimolecular Fluorescence …

…, KF Ejendal, MP Hayes, M Soto-Velasquez… - Cells, 2019 - mdpi.com
Adenylyl cyclase type 5 (AC5), as the principal isoform expressed in striatal medium spiny
neurons (MSNs), is essential for the integration of both stimulatory and inhibitory midbrain …

Molecular modeling evaluation of the enantiomers of a novel adenylyl cyclase 2 inhibitor

N Rana, JM Conley, M Soto-Velasquez… - Journal of chemical …, 2017 - ACS Publications
Adenylyl cyclase 2 (AC2) is one of nine membrane-bound isoforms of adenylyl cyclase that
converts ATP into cyclic AMP (cAMP), an important second messenger molecule. …

Nucleobase Modified Adefovir (PMEA) Analogues as Potent and Selective Inhibitors of Adenylate Cyclases from Bordetella pertussis and Bacillus anthracis

…, H Mertlíková‐Kaiserová, MP SotoVelasquez… - …, 2018 - Wiley Online Library
A series of 13 acyclic nucleoside phosphonates (ANPs) as bisamidate prodrugs was prepared.
Five compounds were found to be non‐cytotoxic and selective inhibitors of Bordetella …

Optimization of a Pyrimidinone Series for Selective Inhibition of Ca2+/Calmodulin-Stimulated Adenylyl Cyclase 1 Activity for the Treatment of Chronic Pain

JA Scott, M Soto-Velasquez, MP Hayes… - Journal of medicinal …, 2022 - ACS Publications
Adenylyl cyclase type 1 (AC1) is involved in signaling for chronic pain sensitization in the
central nervous system and is an emerging target for the treatment of chronic pain. AC1 and a …

Acyclic nucleoside phosphonates with 2-aminothiazole base as inhibitors of bacterial and mammalian adenylate cyclases

…, H Mertlíková-Kaiserová, MP Soto-Velasquez… - European journal of …, 2021 - Elsevier
A series of novel acyclic nucleoside phosphonates (ANPs) was synthesized as potential
adenylate cyclase inhibitors, where the adenine nucleobase of adefovir (PMEA) was replaced …

Synthesis of α‐Branched Acyclic Nucleoside Phosphonates as Potential Inhibitors of Bacterial Adenylate Cyclases

…, M Lepšík, M SotoVelasquez… - …, 2018 - Wiley Online Library
Inhibition of Bordetella pertussis adenylate cyclase toxin (ACT) and Bacillus anthracis edema
factor (EF), key virulence factors with adenylate cyclase activity, represents a potential …