User profiles for Monica Soto-Velasquez
MONICA LUCIA SOTO VELASQUEZProfesor Universidad de Antioquia Verified email at udea.edu.co Cited by 848 |
Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties
TF Brust, D Alongkronrusmee, M Soto-Velasquez… - Science …, 2017 - science.org
Adenylyl cyclase 1 (AC1) belongs to a group of adenylyl cyclases (ACs) that are stimulated
by calcium in a calmodulin-dependent manner. Studies with AC1 knockout mice suggest that …
by calcium in a calmodulin-dependent manner. Studies with AC1 knockout mice suggest that …
Optimization of a 1, 3, 4-oxadiazole series for inhibition of Ca2+/calmodulin-stimulated activity of adenylyl cyclases 1 and 8 for the treatment of chronic pain
J Kaur, M Soto-Velasquez, Z Ding… - European journal of …, 2019 - Elsevier
Adenylyl cyclases type 1 (AC1) and 8 (AC8) are group 1 transmembrane adenylyl cyclases (AC)
that are stimulated by Ca 2+ /calmodulin. Studies have shown that mice depleted of …
that are stimulated by Ca 2+ /calmodulin. Studies have shown that mice depleted of …
A novel CRISPR/Cas9-Based cellular model to explore adenylyl cyclase and cAMP signaling
Functional characterization of adenylyl cyclase (AC) isoforms has proven challenging in
mammalian cells because of the endogenous expression of multiple AC isoforms and the high …
mammalian cells because of the endogenous expression of multiple AC isoforms and the high …
Identification of FDA-approved small molecules capable of disrupting the calmodulin–adenylyl cyclase 8 interaction through direct binding to calmodulin
MP Hayes, M Soto-Velasquez, CA Fowler… - ACS chemical …, 2018 - ACS Publications
Adenylyl cyclases (AC) catalyze the formation of cyclic AMP (cAMP) from ATP and are
involved in a number of disease states, making them attractive potential drug targets. AC8, in …
involved in a number of disease states, making them attractive potential drug targets. AC8, in …
[HTML][HTML] Identification of Novel Adenylyl Cyclase 5 (AC5) Signaling Networks in D1 and D2 Medium Spiny Neurons using Bimolecular Fluorescence …
…, KF Ejendal, MP Hayes, M Soto-Velasquez… - Cells, 2019 - mdpi.com
Adenylyl cyclase type 5 (AC5), as the principal isoform expressed in striatal medium spiny
neurons (MSNs), is essential for the integration of both stimulatory and inhibitory midbrain …
neurons (MSNs), is essential for the integration of both stimulatory and inhibitory midbrain …
Molecular modeling evaluation of the enantiomers of a novel adenylyl cyclase 2 inhibitor
N Rana, JM Conley, M Soto-Velasquez… - Journal of chemical …, 2017 - ACS Publications
Adenylyl cyclase 2 (AC2) is one of nine membrane-bound isoforms of adenylyl cyclase that
converts ATP into cyclic AMP (cAMP), an important second messenger molecule. …
converts ATP into cyclic AMP (cAMP), an important second messenger molecule. …
Nucleobase Modified Adefovir (PMEA) Analogues as Potent and Selective Inhibitors of Adenylate Cyclases from Bordetella pertussis and Bacillus anthracis
…, H Mertlíková‐Kaiserová, MP Soto‐Velasquez… - …, 2018 - Wiley Online Library
A series of 13 acyclic nucleoside phosphonates (ANPs) as bisamidate prodrugs was prepared.
Five compounds were found to be non‐cytotoxic and selective inhibitors of Bordetella …
Five compounds were found to be non‐cytotoxic and selective inhibitors of Bordetella …
Optimization of a Pyrimidinone Series for Selective Inhibition of Ca2+/Calmodulin-Stimulated Adenylyl Cyclase 1 Activity for the Treatment of Chronic Pain
Adenylyl cyclase type 1 (AC1) is involved in signaling for chronic pain sensitization in the
central nervous system and is an emerging target for the treatment of chronic pain. AC1 and a …
central nervous system and is an emerging target for the treatment of chronic pain. AC1 and a …
Acyclic nucleoside phosphonates with 2-aminothiazole base as inhibitors of bacterial and mammalian adenylate cyclases
…, H Mertlíková-Kaiserová, MP Soto-Velasquez… - European journal of …, 2021 - Elsevier
A series of novel acyclic nucleoside phosphonates (ANPs) was synthesized as potential
adenylate cyclase inhibitors, where the adenine nucleobase of adefovir (PMEA) was replaced …
adenylate cyclase inhibitors, where the adenine nucleobase of adefovir (PMEA) was replaced …
Synthesis of α‐Branched Acyclic Nucleoside Phosphonates as Potential Inhibitors of Bacterial Adenylate Cyclases
…, M Lepšík, M Soto‐Velasquez… - …, 2018 - Wiley Online Library
Inhibition of Bordetella pertussis adenylate cyclase toxin (ACT) and Bacillus anthracis edema
factor (EF), key virulence factors with adenylate cyclase activity, represents a potential …
factor (EF), key virulence factors with adenylate cyclase activity, represents a potential …